Clinical trialNCT05327010RecruitingPhase 2Interventional

Testing the Combination of the Anti-cancer Drugs ZEN003694 (ZEN-3694) and Talazoparib in Patients With Advanced Solid Tumors, The ComBET Trial

SponsorNational Cancer Institute (NCI)Enrollment88Advanced Malignant Solid NeoplasmMetastatic Malignant Solid NeoplasmUnresectable Malignant Solid Neoplasm

View the registry record on ClinicalTrials.gov

Summary

The registered summary isn't in our current data snapshot. Read it on the ClinicalTrials.gov record ↗. Why? →

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Timothy A Yap
University of Texas MD Anderson Cancer Center LAO
Principal InvestigatorKOL profile →
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

36 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

City of Hope Comprehensive Cancer Center
Duarte, California, United States
Jyoti Malhotra
Recruiting
City of Hope at Irvine Lennar
Irvine, California, United States
Jyoti Malhotra
Recruiting
Uc San Diego Moores Cancer Center
La Jolla, California, United States
Rana R. McKay →
Recruiting
Keck Medicine of Usc Koreatown
Los Angeles, California, United States
Active, not recruiting
Los Angeles General Medical Center
Los Angeles, California, United States
Active, not recruiting
Usc / Norris Comprehensive Cancer Center
Los Angeles, California, United States
Active, not recruiting
Usc Norris Oncology/hematology-Newport Beach
Newport Beach, California, United States
Active, not recruiting
University of California Davis Comprehensive Cancer Center
Sacramento, California, United States
Active, not recruiting
Uc San Diego Medical Center - Hillcrest
San Diego, California, United States
Rana R. McKay →
Recruiting
Uchealth University of Colorado Hospital
Aurora, Colorado, United States
Active, not recruiting
Yale University
New Haven, Connecticut, United States
Active, not recruiting
Smilow Cancer Hospital Care Center-Trumbull
Trumbull, Connecticut, United States
Active, not recruiting
Uf Health Cancer Institute - Gainesville
Gainesville, Florida, United States
Active, not recruiting
Emory University Hospital/winship Cancer Institute
Atlanta, Georgia, United States
Ticiana A. Leal
Recruiting
Northwestern University
Chicago, Illinois, United States
Aparna Kalyan
Recruiting
University of Kansas Clinical Research Center
Fairway, Kansas, United States
Joaquina C. Baranda
Recruiting
University of Kansas Cancer Center
Kansas City, Kansas, United States
Joaquina C. Baranda
Recruiting
University of Kansas Cancer Center-Overland Park
Overland Park, Kansas, United States
Joaquina C. Baranda
Recruiting
University of Kansas Hospital-Indian Creek Campus
Overland Park, Kansas, United States
Joaquina C. Baranda
Recruiting
University of Kansas Hospital-Westwood Cancer Center
Westwood, Kansas, United States
Joaquina C. Baranda
Recruiting
University of Kentucky/markey Cancer Center
Lexington, Kentucky, United States
Rachel W. Miller
Recruiting
Ochsner Medical Center Jefferson
New Orleans, Louisiana, United States
Daniel Johnson
Recruiting
National Cancer Institute Developmental Therapeutics Clinic
Bethesda, Maryland, United States
A P. Chen
Recruiting
National Institutes of Health Clinical Center
Bethesda, Maryland, United States
Active, not recruiting
University of Kansas Cancer Center - North
Kansas City, Missouri, United States
Joaquina C. Baranda
Recruiting
University of Kansas Cancer Center - Lee'S Summit
Lee's Summit, Missouri, United States
Joaquina C. Baranda
Recruiting
University of Kansas Cancer Center at North Kansas City Hospital
North Kansas City, Missouri, United States
Suspended
Unc Lineberger Comprehensive Cancer Center
Chapel Hill, North Carolina, United States
Shetal Patel
Recruiting
University of Pittsburgh Cancer Institute (upci)
Pittsburgh, Pennsylvania, United States
Leonard J. Appleman
Recruiting
University of Texas at Austin
Austin, Texas, United States
Active, not recruiting
University of Texas Medical Branch
Galveston, Texas, United States
Maurice Willis
Recruiting
Ut Md Anderson Cancer Center
Houston, Texas, United States
Timothy A. Yap
Recruiting
University of Texas Health Science Center at San Antonio
San Antonio, Texas, United States
John Sarantopoulos
Recruiting
Huntsman Cancer Institute/university of Utah
Salt Lake City, Utah, United States
Active, not recruiting
University of Virginia Cancer Center
Charlottesville, Virginia, United States
Linda R. Duska
Recruiting
Vcu Massey Comprehensive Cancer Center
Richmond, Virginia, United States
Emily N. Kinsey
Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

BET Bromodomain Inhibitor ZEN-3694 →Talazoparib →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 14 Nov 2022
Primary completion: 31 Dec 2026
Completion: 31 Dec 2027
Last update posted: 10 Jul 2026
Registered enrollment: 88
Registry id: NCT05327010

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 12 Jul 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.