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Clinical trialNCT05372614SuspendedPhase 1Interventional

Testing the Safety and Tolerability of the Anti-cancer Drugs Trastuzumab Deruxtecan and Neratinib for Cancers With Changes in the HER2 Gene

SponsorNational Cancer Institute (NCI)Enrollment33Metastatic Malignant Solid NeoplasmUnresectable Malignant Solid Neoplasm
View the registry record on ClinicalTrials.gov

Summary

The registered summary isn't in our current data snapshot. Read it on the ClinicalTrials.gov record ↗. Why? →

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

18 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States
  • City of Hope Comprehensive Cancer Center

    Duarte, California, United States

  • City of Hope at Irvine Lennar

    Irvine, California, United States

  • Uci Health - Chao Family Comprehensive Cancer Center and Ambulatory Care

    Irvine, California, United States

  • City of Hope Antelope Valley

    Lancaster, California, United States

  • Uc Irvine Health/chao Family Comprehensive Cancer Center

    Orange, California, United States

  • University of California Davis Comprehensive Cancer Center

    Sacramento, California, United States

  • City of Hope South Pasadena

    South Pasadena, California, United States

  • City of Hope Upland

    Upland, California, United States

  • Uf Health Cancer Institute - Gainesville

    Gainesville, Florida, United States

  • Northwestern University

    Chicago, Illinois, United States

  • University of Kentucky/markey Cancer Center

    Lexington, Kentucky, United States

  • Dana-Farber Cancer Institute

    Boston, Massachusetts, United States

  • Washington University School of Medicine

    St Louis, Missouri, United States

  • Ohio State University Comprehensive Cancer Center

    Columbus, Ohio, United States

  • University of Pittsburgh Cancer Institute (upci)

    Pittsburgh, Pennsylvania, United States

  • Ut Md Anderson Cancer Center

    Houston, Texas, United States

  • University of Wisconsin Carbone Cancer Center - Eastpark Medical Center

    Madison, Wisconsin, United States

  • University of Wisconsin Carbone Cancer Center - University Hospital

    Madison, Wisconsin, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study — it may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
5 Oct 2022
Primary completion
17 Sept 2025
Completion
23 Jan 2027
Last update posted
17 Jun 2026
Registered enrollment
33
Registry id
NCT05372614

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 12 Jul 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.