Clinical trialNCT05538208RecruitingPhase 2Interventional

The Pediatric Lupus Nephritis Mycophenolate Mofetil (PLUMM) Study

SponsorChildren's Hospital Medical Center, CincinnatiEnrollment105Lupus Nephritis

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The study is a 1-year 2-part double-blinded placebo controlled 2-arm clinical trial. Treatment arms are (1) MMF dosed as per body-surface area (MMFBSA; 600mg/m2 body surface area per dose about every 12 hours) and (2) pharmacokinetically-guided precision-dosing of MMF (MMFPK; MMF dosed twice daily to achieve an area under the concentration-time curve (AUC0-12h) of MPA \>60-70 mg\*h/L. The study goal is to determine the safety and efficacy of MMFPK compared to MMFBSA for the treatment of proliferative LN in subjects 8 to \<21 years.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Hermine I Brunner, MD
Children's Hospital Medical Center, Cincinnati
Principal InvestigatorKOL profile →
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

19 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

University of California, San Francisco
San Francisco, California, United States
Emily von Scheven, M.D., M.A.S.
Recruiting
Children'S Hospital Colorado
Aurora, Colorado, United States
Katharine Moore, MD
Recruiting
Emory Children'S Center
Atlanta, Georgia, United States
Larry Greenbaum, MD, MPH
Recruiting
Ann & Robert H. Lurie Children'S Hospital of Chicago
Chicago, Illinois, United States
Pooja Patel, DO
Recruiting
University of Chicago Medicine- Comer Children'S
Chicago, Illinois, United States
Coughi Edens, MD
Recruiting
Washington University in St. Louis School of Medicine
St Louis, Missouri, United States
Brian Stotter, MD
Recruiting
Hackensack University Medical Center
Hackensack, New Jersey, United States
Anna Carmela Gironella, MD
Recruiting
Children'S Hospital at Montefiore
New York, New York, United States
Beatrice Goilav, MDDawn Wahezi, MD
Recruiting
Hospital for Special Surgery
New York, New York, United States
Karen Onel, MD
Recruiting
University of North Carolina at Chapel Hill
Chapel Hill, North Carolina, United States
Eveline Wu, MDLaura Cannon, MD
Recruiting
Akron Children'S Hospital
Akron, Ohio, United States
Kathryn Cook, DO
Recruiting
Cincinnati Children'S Hospital Medical Center
Cincinnati, Ohio, United States
Hermine I Brunner, MD →
Recruiting
University Hospitals Cleveland Medical Center
Cleveland, Ohio, United States
R. Ezequiel Borgia, M.D M.S
Recruiting
Nationwide Children'S Hospital
Columbus, Ohio, United States
Stacy Ardoin, M.D., M.S.
Recruiting
Medical University of South Carolina
Charleston, South Carolina, United States
Natasha Ruth, M.D., M.S.
Recruiting
Baylor College of Medicine Pediatric Immunology Allergy Rheumatology
Houston, Texas, United States
Marietta DeGuzman, MD
Recruiting
University of Utah
Salt Lake City, Utah, United States
Aimee Hersh, MD
Recruiting
Seattle Children'S Hospital/university of Washington
Seattle, Washington, United States
Kristen Hayward, MD, MS
Recruiting
Children'S Wisconsin/medical College of Wisconsin
Milwaukee, Wisconsin, United States
Ellen Cody, MD
Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Mycophenolate mofetil →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 7 Jun 2024
Primary completion: 31 Jul 2026
Completion: 31 Jan 2027
Last update posted: 18 Mar 2026
Registered enrollment: 105
Registry id: NCT05538208

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.