Clinical trialNCT05647265RecruitingPhase 2Interventional

Testing the Addition of Immunotherapy Before Surgery for Patients With Sarcomatoid Mesothelioma

SponsorAlliance for Clinical Trials in OncologyEnrollment26Pleural Biphasic MesotheliomaPleural Sarcomatoid Mesothelioma

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This phase II trial evaluates the safety and effectiveness of giving immunotherapy (nivolumab and ipilimumab) before surgery for controlling disease in patients with stage I-IIIa sarcomatoid mesothelioma. Immunotherapy with monoclonal antibodies, such as nivolumab and ipilimumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Giving immunotherapy before surgery may be more effective at controlling disease in patients with sarcomatoid mesothelioma than giving immunotherapy alone.

clinicaltrials.gov ↗

Investigators

No overall officials are registered on this study record. Site-level investigators, where published, appear with their sites below. Why? →

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

132 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Alaska Breast Care and Surgery Llc
Anchorage, Alaska, United States
Alison K. Conlin
Recruiting
Alaska Oncology and Hematology Llc
Anchorage, Alaska, United States
Alison K. Conlin
Recruiting
Alaska Women'S Cancer Care
Anchorage, Alaska, United States
Alison K. Conlin
Recruiting
Anchorage Associates in Radiation Medicine
Anchorage, Alaska, United States
Alison K. Conlin
Recruiting
Anchorage Radiation Therapy Center
Anchorage, Alaska, United States
Suspended
Katmai Oncology Group
Anchorage, Alaska, United States
Alison K. Conlin
Recruiting
Providence Alaska Medical Center
Anchorage, Alaska, United States
Alison K. Conlin
Recruiting
Kingman Regional Medical Center
Kingman, Arizona, United States
John A. Ellerton
Recruiting
Mayo Clinic Hospital in Arizona
Phoenix, Arizona, United States
Aaron S. Mansfield
Recruiting
Mayo Clinic in Arizona
Scottsdale, Arizona, United States
Aaron S. Mansfield
Recruiting
Pcr Oncology
Arroyo Grande, California, United States
John A. Ellerton
Recruiting
Providence Saint Joseph Medical Center/disney Family Cancer Center
Burbank, California, United States
Alison K. Conlin
Recruiting
Uc San Diego Moores Cancer Center
La Jolla, California, United States
Lyudmila A. Bazhenova
Recruiting
Providence Queen of the Valley
Napa, California, United States
Alison K. Conlin
Recruiting
Providence Medical Foundation - Santa Rosa
Santa Rosa, California, United States
Alison K. Conlin
Recruiting
Providence Santa Rosa Memorial Hospital
Santa Rosa, California, United States
Alison K. Conlin
Recruiting
Beebe Medical Center
Lewes, Delaware, United States
Active, not recruiting
Beebe South Coastal Health Campus
Millville, Delaware, United States
Active, not recruiting
Christiana Care Health System-Christiana Hospital
Newark, Delaware, United States
Active, not recruiting
Delaware Clinical and Laboratory Physicians Pa
Newark, Delaware, United States
Active, not recruiting
Helen F Graham Cancer Center
Newark, Delaware, United States
Active, not recruiting
Medical Oncology Hematology Consultants Pa
Newark, Delaware, United States
Active, not recruiting
Beebe Health Campus
Rehoboth Beach, Delaware, United States
Active, not recruiting
Christiana Care Health System-Wilmington Hospital
Wilmington, Delaware, United States
Active, not recruiting
Mayo Clinic in Florida
Jacksonville, Florida, United States
Aaron S. Mansfield
Recruiting
Saint Luke'S Cancer Institute - Boise
Boise, Idaho, United States
Alison K. Conlin
Recruiting
Saint Luke'S Cancer Institute - Fruitland
Fruitland, Idaho, United States
Alison K. Conlin
Recruiting
Saint Luke'S Cancer Institute - Meridian
Meridian, Idaho, United States
Alison K. Conlin
Recruiting
Saint Luke'S Cancer Institute - Nampa
Nampa, Idaho, United States
Alison K. Conlin
Recruiting
Saint Luke'S Cancer Institute - Twin Falls
Twin Falls, Idaho, United States
Alison K. Conlin
Recruiting
Rush-Copley Medical Center
Aurora, Illinois, United States
Tanmay Sahai
Recruiting
Northwestern University
Chicago, Illinois, United States
Young Kwang Chae
Recruiting
University of Chicago Comprehensive Cancer Center
Chicago, Illinois, United States
Hedy L. Kindler →
Recruiting
Carle at the Riverfront
Danville, Illinois, United States
Tanmay Sahai
Recruiting
Northwestern Medicine Cancer Center Kishwaukee
DeKalb, Illinois, United States
Young Kwang Chae
Recruiting
Carle Physician Group-Effingham
Effingham, Illinois, United States
Tanmay Sahai
Recruiting
Northwestern Medicine Cancer Center Delnor
Geneva, Illinois, United States
Young Kwang Chae
Recruiting
Northwestern Medicine Glenview Outpatient Center
Glenview, Illinois, United States
Young Kwang Chae
Recruiting
Northwestern Medicine Grayslake Outpatient Center
Grayslake, Illinois, United States
Young Kwang Chae
Recruiting
Northwestern Medicine Lake Forest Hospital
Lake Forest, Illinois, United States
Young Kwang Chae
Recruiting

92 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Ipilimumab →Nivolumab →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 27 Nov 2024
Primary completion: 15 Dec 2026
Completion: 15 Dec 2026
Last update posted: 5 Aug 2026
Registered enrollment: 26
Registry id: NCT05647265

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.