Clinical trialNCT05768139RecruitingPhase 1/PHASE2Interventional

First-in-Human Study of Tersolisib (STX-478) as Monotherapy and in Combination With Other Antineoplastic Agents in Participants With Advanced Solid Tumors

SponsorEli Lilly and CompanyEnrollment880Breast CancerSolid Tumors, Adult

View the registry record on ClinicalTrials.gov

Summary

The registered summary isn't in our current data snapshot. Read it on the ClinicalTrials.gov record ↗. Why? →

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 8 AM - 8 PM Eastern time (UTC/GMT - 5 hours, EST)
Eli Lilly and Company
Study Director
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

65 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Belgium

Institut Jules Bordet
Anderlecht, Belgium
Philippe Aftimos
Recruiting
Uz Leuven
Leuven, Belgium
Patrick Neven
Recruiting

France

Institut Bergonié - Centre Régional de Lutte Contre Le Cancer de Bordeaux Et Sud Ouest
Bordeaux, France
Maxime Brunet
Recruiting
Centre Leon Berard
Lyon, France
Isabelle Ray-Coquard
Recruiting
Institut Paoli-Calmettes
Marseille, France
Cecile Vicier
Recruiting
Centre Antoine-Lacassagne
Nice, France
Philippe Follana
Recruiting
Institut Claudius Regaud
Toulouse, France
Eleonora De Maio
Recruiting
Gustave Roussy
Villejuif, France
Barbara Pistilli
Recruiting

Germany

Universitätsklinikum Erlangen
Erlangen, Germany
Peter Fasching
Not, yet, recruiting

Ireland

Mater Misericordiae Hospital
Dublin, Ireland
Austin Duffy
Recruiting

Italy

Azienda Ospedaliera Nazionale Santi Antonio E Biagio E Cesare Arrigo
Alessandria, Italy
Giulia Gallizzi
Recruiting
Spedali Civili Di Brescia
Brescia, Italy
Rebecca Pedersini
Not, yet, recruiting
Istituto Europeo Di Oncologia
Milan, Italy
Giuseppe Curigliano
Recruiting
Istituto Nazionale Per Lo Studio E la Cura Dei Tumori
Milan, Italy
Giulia Bianchi
Recruiting
Fondazione Irccs San Gerardo Dei Tintori
Monza, Italy
Marina Cazzaniga
Recruiting
Azienda Ospedaliero Universitaria Pisana - Stabilimento Santa Chiara
Pisa, Italy
Carmelo Bengala
Recruiting
Ospedale Santa Maria Delle Croci
Ravenna, Italy
Stefano Tamberi
Recruiting
Fondazione Policlinico Universitario Agostino Gemelli
Roma, Italy
Gennaro Daniele
Recruiting
Centro Ricerche Cliniche Di Verona S.R.L.
Verona, Italy
Andrea Zivi
Recruiting

Japan

National Hospital Organization Kyushu Cancer Center
Fukuoka, Japan
Eriko Tokunaga
Recruiting
Kansai Medical University Hospital
Hirakata, Japan
Toshio Shimizu
Recruiting
Kyoto University Hospital
Kyoto, Japan
TAKAKO NAKAJIMA
Recruiting
the Cancer Institute Hospital of Jfcr
Kōtō City, Japan
Yukinori Ozaki
Recruiting

Netherlands

Netherlands Cancer Institute
Amsterdam, Netherlands
Marloes G.J. van Dongen
Recruiting
Erasmus Mc
Rotterdam, Netherlands
Agnes Jager
Recruiting

Spain

Hospital Quiron Barcelona
Barcelona, Spain
Guzman Alonso Casal
Recruiting
Hospital Universitari Vall D'Hebron
Barcelona, Spain
Cristina Saura Manich
Recruiting
Instituto Oncologico Dr Rosell (ior)
Barcelona, Spain
Jose Manuel Perez Garcia
Recruiting
South Texas Accelerated Research Therapeutics (start) Barcelona- Hm Nou Delfos
Barcelona, Spain
Tatiana Hernandez Guerrero
Recruiting
Hospital San Pedro
Logroño, Spain
Maria Jose de Miguel Luken
Recruiting
Hospital Clinico San Carlos
Madrid, Spain
Jorge Bartolome Arcilla
Recruiting
Hospital Universitario Fundación Jiménez Díaz
Madrid, Spain
Bernard Doger de Speville Uribe
Recruiting
Hospital Universitario Hm Sanchinarro
Madrid, Spain
Juan Jose Soto
Recruiting
Md Anderson Cancer Center
Madrid, Spain
Maria Calvo Plaza
Recruiting
Hospital Universitario Quironsalud Madrid
Pozuelo de Alarcón, Spain
Valentina Boni
Recruiting
Hospital Universitari Sant Joan de Reus
Reus, Spain
Kepa Amillano Parraga
Recruiting
Hospital Universitario Virgen Macarena
Seville, Spain
Luis de la Cruz Merino
Recruiting

United States

Ellison Clinic at Saint John'S
Los Angeles, California, United States
Reva Basho
Recruiting
Ucsf Medical Center at Mission Bay
San Francisco, California, United States
Varun Monga
Recruiting
University of Colorado Cancer Center
Aurora, Colorado, United States
Anthony Elias
Recruiting

25 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Abemaciclib →Anastrozole →Exemestane →Fulvestrant →ImlunestrantLetrozole →Metformin →Palbociclib →Ribociclib →TersolisibTamoxifen →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 17 Apr 2023
Primary completion: 31 Jul 2030
Completion: 31 Jul 2030
Last update posted: 7 Jul 2026
Registered enrollment: 880
Registry id: NCT05768139

Cross-registrations

EU-CTR / CTIS (EudraCT)2023-504807-94-00EU-CTR / CTIS (EudraCT)2023-000442-41

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 12 Jul 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.