Clinical trialNCT05943535RecruitingPhase 3Interventional

Study of the Efficacy and Safety of Inhaled Treprostinil in Subjects With Progressive Pulmonary Fibrosis (TETON-PPF)

SponsorUnited TherapeuticsEnrollment698Interstitial Lung DiseaseProgressive Pulmonary Fibrosis

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

Study RIN-PF-305 is designed to evaluate the safety and efficacy of inhaled treprostinil in subjects with progressive pulmonary fibrosis (PPF) over a 52-week period.

clinicaltrials.gov ↗

Investigators

No overall officials are registered on this study record. Site-level investigators, where published, appear with their sites below. Why? →

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

165 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Argentina

Instituto Ave Pulmo - Fundacion Enfisema
Mar del Plata, Buenos Aires, Argentina
Luis Arturo Wehbe, MD
Recruiting
Instituto Medico Rio Cuarto
Río Cuarto, Córdoba Province, Argentina
Mauricio J Eceiza, MD
Recruiting
Sanatorio Parque de Rosario - Consultorios Externos
Rosario, Santa Fe Province, Argentina
Silvina Mannarino, MD
Recruiting
Cimer-Centro Integral de Medicina Respiratoria
San Miguel de Tucumán, Tucumán Province, Argentina
Altieri Hector, MD
Recruiting
Investigaciones En Patologias Respiratorias
San Miguel de Tucumán, Tucumán Province, Argentina
Ramon A Rojas, MD
Recruiting
Cinme Centro de Investigaciones Metabolicas
Buenos Aires, Argentina
Maria Otaola, MD
Recruiting
Fundación Respirar
Buenos Aires, Argentina
María Cristina De Salvo, MD
Recruiting
Instituto de Medicina Respiratoria
Córdoba, Argentina
Alexis Cazaux, MD
Recruiting
Sanatorio Allende Cerro
Córdoba, Argentina
Viviana Alejandra Moyano
Recruiting

Australia

Royal Prince Alfred Hospital
Camperdown, New South Wales, Australia
Tamera Corte, Prof.
Recruiting
St George Hospital
Kogarah, New South Wales, Australia
Alexandra Smith, MD
Recruiting
the Prince Charles Hospital
Brisbane, Queensland, Australia
John Andrew Mackintosh
Recruiting
Lung Research Qld
Chermside, Queensland, Australia
Daniel Chambers
Recruiting
Eastern Health Box Hill Hospital
Box Hill, Victoria, Australia
Francis Thien, MD
Recruiting
Monash Health-Monash Medical Centre
Clayton, Victoria, Australia
Xun Li, MD
Recruiting
Austin Health
Heidelberg, Victoria, Australia
Nicole Soo Goh, MD
Recruiting
Institute for Respiratory Health - Midland
Midland, Western Australia, Australia
David Manners, MD
Recruiting
Institute for Respiratory Health
Nedlands, Western Australia, Australia
Vidya Navaratnam, MD
Recruiting

Belgium

Azorg
Aalst, Belgium
Valerie Adam, MD
Recruiting
Zas Middelheim
Antwerp, Belgium
Hans Slabbynck, MD
Recruiting
Cub Hopital Erasmde
Brussels, Belgium
Benjamin Bondue, MD
Recruiting
Cliniques Universitaires St.-Luc
Brussels, Belgium
Antoine Froidure, MD
Recruiting
Universitair Ziekenhuis Gent
Ghent, Belgium
Geert Van Pottelberge, MD
Recruiting
Uz Leuven
Leuven, Belgium
Wim Wuyts, MD
Recruiting
Chu de Liège
Liège, Belgium
Julien Guiot, MD
Recruiting

Canada

St.Paul'S Hospital
Vancouver, British Columbia, Canada
Christopher Ryerson, MD
Recruiting
Dynamic Drug Advancement Limited
Ajax, Ontario, Canada
George Philteos, MD
Recruiting
St.Joseph'S Healthcare Hamilton
Hamilton, Ontario, Canada
Nathan Hambly, MD
Recruiting
Hôpital Maisonneuve-Rosemont
Montreal, Quebec, Canada
Ping Shi Zhu, MD
Recruiting
Cic Mauricie Inc.
Québec, Quebec, Canada
Émilie Millaire, MD
Recruiting
Diex Recherche Inc. - Division Sherbrooke Est
Sherbrooke, Quebec, Canada
Christophe He, MD
Recruiting
Royal University Hospital
Saskatoon, Saskatchewan, Canada
Veronica Marcoux, Dr.
Recruiting

Chile

Centro de Investigacion Curico
Curicó, Maule Region, Chile
Victor Antonio Martinez Hagen, MD
Recruiting
Biocinetic Ltda.
Santiago, Santiago Metropolitan, Chile
Ricardo Alexis Fritz Garrido, MD
Recruiting
Cec Centro Estudios Clinicos
Santiago, Santiago Metropolitan, Chile
Georgina Viviana Miranda Saez, MD
Recruiting
Fundacion Medica San Cristobal
Santiago, Santiago Metropolitan, Chile
Ricardo Luis Sepulveda Moncayo, MD
Recruiting
Centro Respiratorio Integral Ltda. (cenresin)
Quillota, Valparaiso, Chile
Juana Rosa Pavie Gallegos, MD
Recruiting
Centro de Investigación de Enfermedades Respiratorias E Inmunológicas (cieri)
Viña del Mar, Valparaiso, Chile
Felipe Eduardo Saavedra Gonzalez, MD
Recruiting

France

Hôpital Avicennes
Bobigny, France
Hilario Nunes, MD
Recruiting
Hospices Civils de Lyon - Hôpital Louis Pradel
Bron, France
Vincent Cottin, MD
Recruiting

125 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Inhaled TreprostinilPlacebo

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 30 Oct 2023
Primary completion: 30 Nov 2027
Completion: 30 Nov 2027
Last update posted: 13 Jul 2026
Registered enrollment: 698
Registry id: NCT05943535

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.