Clinical trialNCT06045923TerminatedObservational

Virologic and Immunologic Characteristics of Severe Mpox in Persons With Advanced HIV

SponsorCenters for Disease Control and PreventionEnrollment100AIDSHIV InfectionsMonkeypox

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The purpose of this study is to examine the extent of mpox viral spread and immunologic markers in people with advanced HIV. Study findings will enhance knowledge of mpox pathogenesis in severely immunocompromised people, which can inform treatment and prevention of severe illness and deaths associated with mpox in people with advanced HIV.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Agam Rao, MD
Centers for Disease Control and Prevention
Principal Investigator
clinicaltrials.gov ↗
Brian Epling, MD
National Institutes of Health (NIH)
Study Director
clinicaltrials.gov ↗
Christine Hughes, PhD
Centers for Disease Control and Prevention
Study Director
clinicaltrials.gov ↗
Faisal Minhaj, Pharm.D.
Centers for Disease Control and Prevention
Study Director
clinicaltrials.gov ↗
Irini Sereti, MD
National Institutes of Health (NIH)
Study Director
clinicaltrials.gov ↗
Jason Zucker, MD
Columbia University
Study Director
clinicaltrials.gov ↗
Jesse OShea, MD
Centers for Disease Control and Prevention
Study Director
clinicaltrials.gov ↗
Katy Saliba, PhD
National Institutes of Health (NIH)
Study Director
clinicaltrials.gov ↗
Sarah Park, MD
Karius Laboratories
Study Director
clinicaltrials.gov ↗
Sarah Reagan Steiner, MD
Centers for Disease Control and Prevention
Study Director
clinicaltrials.gov ↗
Shama Cash-Goldwasser, MD
Centers for Disease Control and Prevention
Study Director
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

1 registered facility, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Centers for Disease Control and Prevention
Atlanta, Georgia, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study. It may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 17 Mar 2023
Primary completion: 1 Jan 2026
Completion: 1 Jan 2026
Last update posted: 5 May 2026
Registered enrollment: 100
Registry id: NCT06045923

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.