Clinical trialNCT06065657Active, not recruitingPhase 2/PHASE3Interventional

Effect of Nutritional Ketosis on Alcohol Metabolism

SponsorUniversity of PennsylvaniaEnrollment23Alcohol DrinkingAlcohol IntoxicationKetogenic DietingKetoses, MetabolicMagnetic Resonance Imaging

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The research study is being conducted in health controls to better understand the effects of ketosis on brain functioning after 3 different, randomly assigned, 3-day dietary interventions and the acute effects of alcohol after consuming about 4-5 alcohol beverages. The labs visits will use magnetic resonance imaging (MRI) scans to study the brain, measuring levels of nicotinamide adenine dinucleotide (NAD), lactate, neurotransmitters glutamate, and Gamma-aminobutyric acid (GABA).

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Corinde Wiers, Ph.D.
University of Pennsylvania
Principal Investigator
clinicaltrials.gov ↗
Henry Kranzler, MD
University of Pennsylvania
Study Director
clinicaltrials.gov ↗
Kyle Kampman, MD
University of Pennsylvania
Study DirectorKOL profile →
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

1 registered facility, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

University of Pennsylvania Center for Studies of Addiction
Philadelphia, Pennsylvania, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Ethanol

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 29 Feb 2024
Primary completion: 1 Dec 2025
Completion: 1 Dec 2026
Last update posted: 7 Apr 2026
Registered enrollment: 23
Registry id: NCT06065657

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.