Clinical trialNCT07420283RecruitingPhase 2Interventional

A Study of Brenipatide in Participants With Opioid Use Disorder

SponsorEli Lilly and CompanyEnrollment465Opioid Use Disorder

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The purpose of this study is to see if brenipatide, when compared to placebo, is safe and effective for participants with opioid use disorder, when used with buprenorphine with or without naloxone. The maximum potential duration of study participation for a participant in Part A is approximately 144 weeks, maximum potential duration of study participation for a participant in Part B is approximately 116 weeks. The actual duration will vary for each participant depending on the time of enrollment and the overall rate of study enrollment.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 8 AM - 8 PM Eastern time (UTC/GMT - 5 hours, EST)
Eli Lilly and Company
Study Director
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

58 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Canada

Care Clinic
Calgary, Canada
Sumantra Ghosh
Recruiting
Med Trust Research
Courtice, Canada
Hamilton Jeyaraj
Recruiting
the Medical Arts Health Research Group
Kamloops, Canada
Dustin Janz
Not, yet, recruiting
Kelowna Health and Memory Centre
Kelowna, Canada
Eugene Okorie
Recruiting
Providence Care
Kingston, Canada
Roumen Milev
Recruiting
Malton Medical Group
Mississauga, Canada
Brian Zidel
Recruiting
Centre for Addiction and Mental Health (camh)
Toronto, Canada
Bernard Le Foll
Recruiting
Comprehensive Treatment Clinic
Toronto, Canada
Leonard Bienenstock
Recruiting

Puerto Rico

Research Works San Juan
Guaynabo, Puerto Rico
Jose Feliberti
Not, yet, recruiting

United Kingdom

Surrey and Borders Partnership Nhs Foundation Trust
Chertsey, United Kingdom
CHRISTOS KOUIMTSIDIS
Recruiting
St Pancras Clinical Research - Eastbourne
Eastbourne, United Kingdom
Graham Campbell
Not, yet, recruiting
Queen Elizabeth University Hospital
Glasgow, United Kingdom
Nagore Penades
Recruiting
Bioluminux - London
London, United Kingdom
Laxmi Patel
Recruiting
Lambeth Drug and Alcohol Treatment Consortium
London, United Kingdom
michael kelleher
Not, yet, recruiting
St Pancras Clinical Research
London, United Kingdom
Ward Lawrence
Not, yet, recruiting
Greater Manchester Mental Health Nhs Foundation Trust
Manchester, United Kingdom
Stephen Kaar
Not, yet, recruiting
Bioluminux Clinical Research - Milton Keynes
Milton Keynes, United Kingdom
Kayode Timothy
Recruiting
Bioluminux - Southampton
Southampton, United Kingdom
Adebayo Jejeloye
Recruiting
Old Bank House Hillingdon Drug & Alcohol
Uxbridge, United Kingdom
Jeffrey Fehler
Not, yet, recruiting
Bioluminux - Wolverhampton
Wolverhampton, United Kingdom
Joshua Olofinlade
Recruiting

United States

Noesispharma - Phoenix - East Shea Boulevard
Phoenix, Arizona, United States
John Prater
Recruiting
Pillar Clinical Research- Little Rock
Little Rock, Arkansas, United States
Leslie Smith
Recruiting
Woodland International Research Group
Little Rock, Arkansas, United States
George Konis
Recruiting
Ark Clinical Research - Fountain Valley
Fountain Valley, California, United States
Justin Yanuck
Recruiting
Center on Substance Use and Health (csuh)
San Francisco, California, United States
Phillip Coffin
Recruiting
Ucsf Weill Institute for Neurosciences - Substance Use Disorders Clinic - Mission Bay
San Francisco, California, United States
Khaled Moussawi
Recruiting
Bradenton Research Center, Inc.
Bradenton, Florida, United States
Eric Folkens
Recruiting
K2 Medical Research - Daytona Beach
Daytona Beach, Florida, United States
Esteban Olivera
Recruiting
Nextphase Research Florida - Hollywood
Hollywood, Florida, United States
Peter Ventre
Recruiting
Accel Research Sites - Lakeland Clinical Research Unit
Lakeland, Florida, United States
James Andersen
Recruiting
Life Arc Research Centers - Miami
Miami, Florida, United States
Janny Rivera
Recruiting
Advanced Research for Health Improvement, Llc
Naples, Florida, United States
Leonard Lado
Recruiting
Innovative Research Institute - Port Charlotte
Port Charlotte, Florida, United States
Joseph Ravid
Recruiting
Better Years Ahead Medical Center
Tampa, Florida, United States
Ana Suarez
Recruiting
Neuroscience Research Institute - West Palm Beach
West Palm Beach, Florida, United States
Danesh Alam
Recruiting
Re:cognition Health - Chicago
Chicago, Illinois, United States
Abid Nazeer
Recruiting
Indiana University Health Neuroscience Center
Indianapolis, Indiana, United States
Michael Bushey
Recruiting
University of Kentucky Chandler Medical Center
Lexington, Kentucky, United States
Shanna Babalonis
Recruiting
Maryland Treatment Centers - Mountain Manor Treatment Center
Baltimore, Maryland, United States
Marc Fishman
Recruiting
Maryland Treatment Centers - Avery Road Treatment Center
Rockville, Maryland, United States
Marc Fishman
Recruiting

18 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

BrenipatideBuprenorphine →Placebo

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 13 Feb 2026
Primary completion: 31 Mar 2028
Completion: 31 Mar 2028
Last update posted: 21 Aug 2026
Registered enrollment: 465
Registry id: NCT07420283

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.