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Clinical trialNCT06429449RecruitingPhase 1Interventional

Mitoxantrone for Venetoclax Resistant Acute Myeloid Leukemia

SponsorUniversity of Colorado, DenverEnrollment30LeukemiaMonocytic LeukemiaMyeloid Leukemia
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This is an open label, phase 1 study for AML subjects with relapsed or refractory disease or subjects in morphologic remission with MRD+ after first line therapy with venetoclax+HMA. A preliminary dose-finding cohort will be followed by 3 expansion cohorts.
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

1 registered facility, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States
  • University of Colorado Hospital

    Aurora, Colorado, United States

    Ajay Major, MDAndrew Kent, MD, PhDBrad Haverkos, MDChristine McMahon, MDDaniel Pollyea, MDDaniel Sherbenou, MDJagar Jasem, MDJonathan Gutman, MDJorge Monge Urrea, MDManali Kamdar, MDMarc Schwartz, MDMaria Amaya, MDMathew Angelos, MDSteven Bair, MD
    Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Azacitidine →Mitoxantrone →Venetoclax →
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
21 Jul 2024
Primary completion
31 Dec 2026
Completion
30 Nov 2027
Last update posted
15 Jan 2026
Registered enrollment
30
Registry id
NCT06429449
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.