Clinical trialNCT06513962RecruitingPhase 3Interventional

Triptorelin for the Prevention of Ovarian Damage in Adolescents and Young Adults With Cancer

SponsorChildren's Oncology GroupEnrollment60Hematopoietic and Lymphatic System NeoplasmMalignant Solid Neoplasm

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This phase III trial compares the effect of giving triptorelin vs no triptorelin in preventing ovarian damage in adolescents and young adults (AYAs) with cancer receiving chemotherapy with an alkylating agents. Alkylating agents are part of standard chemotherapy, but may cause damage to the ovaries. If the ovaries are not working well or completely shut down, then it will be difficult or impossible to get pregnant in the future. Triptorelin works by blocking certain hormones and causing the ovaries to slow down or pause normal activity. The triptorelin used in this study stays active in the body for 24 weeks or about 6 months after a dose is given. After triptorelin is cleared from the body, the ovaries resume normal activities. Adding triptorelin before the start of chemotherapy treatment may reduce the chances of damage to the ovaries.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Eric J Chow
Children's Oncology Group
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

205 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Canada

Cancercare Manitoba
Winnipeg, Manitoba, Canada
Stephanie M. Villeneuve
Recruiting
Centre Hospitalier Universitaire Sainte-Justine
Montreal, Quebec, Canada
Monia Marzouki
Recruiting
the Montreal Children'S Hospital of the Muhc
Montreal, Quebec, Canada
Stephanie Mourad
Recruiting
Chu de Quebec-Centre Hospitalier de L'Universite Laval (chul)
Québec, Canada
Bruno Michon
Recruiting

United States

Children'S Hospital of Alabama
Birmingham, Alabama, United States
Jamie M. Aye
Recruiting
University of Alabama at Birmingham Cancer Center
Birmingham, Alabama, United States
Vanessa Eulo
Recruiting
Usa Health Strada Patient Care Center
Mobile, Alabama, United States
Hamayun Imran
Recruiting
Phoenix Childrens Hospital
Phoenix, Arizona, United States
Alexandra M. Walsh
Recruiting
Banner University Medical Center - Tucson
Tucson, Arizona, United States
Monica M. Davini
Recruiting
Mercy Hospital Fort Smith
Fort Smith, Arkansas, United States
Jay W. Carlson
Recruiting
Arkansas Children'S Hospital
Little Rock, Arkansas, United States
Michael W. Bishop
Recruiting
Carti Cancer Center
Little Rock, Arkansas, United States
Jay W. Carlson
Recruiting
City of Hope Comprehensive Cancer Center
Duarte, California, United States
Rusha Bhandari
Recruiting
Uc San Diego Moores Cancer Center
La Jolla, California, United States
H. I. Su
Recruiting
Loma Linda University Medical Center
Loma Linda, California, United States
Albert Kheradpour
Recruiting
Mattel Children'S Hospital Ucla
Los Angeles, California, United States
Noah C. Federman
Recruiting
Kaiser Permanente-Oakland
Oakland, California, United States
Aarati V. Rao
Recruiting
Children'S Hospital of Orange County
Orange, California, United States
Elyssa M. Rubin
Recruiting
Sutter Medical Center Sacramento
Sacramento, California, United States
Sandra Baril
Recruiting
Rady Children'S Hospital - San Diego
San Diego, California, United States
William D. Roberts
Recruiting
Uc San Diego Medical Center - Hillcrest
San Diego, California, United States
Suspended
Children'S Hospital Colorado
Aurora, Colorado, United States
Jenna M. Demedis
Recruiting
Rocky Mountain Hospital for Children-Presbyterian Saint Luke'S Medical Center
Denver, Colorado, United States
Florence Choo
Recruiting
Connecticut Children'S Medical Center
Hartford, Connecticut, United States
Michael S. Isakoff
Recruiting
Beebe Medical Center
Lewes, Delaware, United States
Gregory A. Masters
Recruiting
Beebe South Coastal Health Campus
Millville, Delaware, United States
Gregory A. Masters
Recruiting
Christiana Care Health System-Christiana Hospital
Newark, Delaware, United States
Gregory A. Masters
Recruiting
Helen F Graham Cancer Center
Newark, Delaware, United States
Gregory A. Masters
Recruiting
Medical Oncology Hematology Consultants Pa
Newark, Delaware, United States
Gregory A. Masters
Recruiting
Beebe Health Campus
Rehoboth Beach, Delaware, United States
Gregory A. Masters
Recruiting
Alfred I Dupont Hospital for Children
Wilmington, Delaware, United States
Vibhuti Agarwal
Recruiting
Christiana Care Health System-Wilmington Hospital
Wilmington, Delaware, United States
Gregory A. Masters
Recruiting
Children'S National Medical Center
Washington D.C., District of Columbia, United States
Jeffrey S. Dome
Recruiting
Golisano Children'S Hospital of Southwest Florida
Fort Myers, Florida, United States
Emad K. Salman
Recruiting
Uf Health Cancer Institute - Gainesville
Gainesville, Florida, United States
Brian Stover
Recruiting
Memorial Regional Hospital/joe Dimaggio Children'S Hospital
Hollywood, Florida, United States
Iftikhar Hanif
Recruiting
Nemours Children'S Clinic-Jacksonville
Jacksonville, Florida, United States
Vibhuti Agarwal
Recruiting
Miami Cancer Institute
Miami, Florida, United States
Doured Daghistani
Recruiting
Nicklaus Children'S Hospital
Miami, Florida, United States
Maggie E. Fader
Recruiting
University of Miami Miller School of Medicine-Sylvester Cancer Center
Miami, Florida, United States
Meghan McCormick
Recruiting

165 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Triptorelin →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 27 Feb 2025
Primary completion: 30 Oct 2029
Completion: 30 Oct 2029
Last update posted: 17 Jul 2026
Registered enrollment: 60
Registry id: NCT06513962

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.