Clinical trialNCT06860594RecruitingPhase 1Interventional

Testing the Addition of an Anti-Cancer Drug, Triapine, to the Usual Radiation Therapy for Recurrent Glioblastoma or Astrocytoma

SponsorNational Cancer Institute (NCI)Enrollment30Astrocytoma, IDH-Mutant, Grade 2Recurrent Adult Diffuse Hemispheric Glioma, H3 G34-MutantRecurrent Adult Diffuse Midline Glioma, H3 K27-MutantRecurrent Astrocytoma, IDH-MutantRecurrent Astrocytoma, IDH-Mutant, Grade 3Recurrent Astrocytoma, IDH-Mutant, Grade 4+1 more conditions

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This phase I trial tests the safety, side effects, and best dose of triapine in combination with radiation therapy in treating patients with glioblastoma or astrocytoma that has come back after a period of improvement (recurrent). Triapine may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Radiation therapy uses high energy x-rays, particles, or radioactive seeds to kill cancer cells and shrink tumors. Giving triapine in combination with radiation therapy may be safe, tolerable, and/or effective in treating patients with recurrent glioblastoma or astrocytoma.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Stephanie M Yoon
City of Hope Comprehensive Cancer Center LAO
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

43 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

City of Hope Comprehensive Cancer Center
Duarte, California, United States
Stephanie M. Yoon
Recruiting
Uci Health - Chao Family Comprehensive Cancer Center and Ambulatory Care
Irvine, California, United States
Jerica M. Lomax
Recruiting
Uc San Diego Moores Cancer Center
La Jolla, California, United States
David E. Piccioni
Recruiting
Uc Irvine Health/chao Family Comprehensive Cancer Center
Orange, California, United States
Jerica M. Lomax
Recruiting
University of California Davis Comprehensive Cancer Center
Sacramento, California, United States
Orwa Aboud
Recruiting
Yale University
New Haven, Connecticut, United States
Nicholas A. Blondin
Recruiting
Smilow Cancer Hospital Care Center-Trumbull
Trumbull, Connecticut, United States
Nicholas A. Blondin
Recruiting
Medstar Georgetown University Hospital
Washington D.C., District of Columbia, United States
Suspended
Um Sylvester Comprehensive Cancer Center at Coral Gables
Coral Gables, Florida, United States
Macarena I. De La Fuente
Recruiting
Um Sylvester Comprehensive Cancer Center at Coral Springs
Coral Springs, Florida, United States
Macarena I. De La Fuente
Recruiting
Um Sylvester Comprehensive Cancer Center at Deerfield Beach
Deerfield Beach, Florida, United States
Macarena I. De La Fuente
Recruiting
Um Sylvester Comprehensive Cancer Center at Doral
Doral, Florida, United States
Macarena I. De La Fuente
Recruiting
Um Sylvester Comprehensive Cancer Center at Hollywood
Hollywood, Florida, United States
Macarena I. De La Fuente
Recruiting
Um Sylvester Comprehensive Cancer Center at Kendall
Miami, Florida, United States
Macarena I. De La Fuente
Recruiting
University of Miami Miller School of Medicine-Sylvester Cancer Center
Miami, Florida, United States
Macarena I. De La Fuente
Recruiting
University of Miami Sylvester Comprehensive Cancer Center at Sole Mia
North Miami, Florida, United States
Macarena I. De La Fuente
Recruiting
Um Sylvester Comprehensive Cancer Center at Plantation
Plantation, Florida, United States
Macarena I. De La Fuente
Recruiting
Emory University Hospital/winship Cancer Institute
Atlanta, Georgia, United States
Kimberly Hoang
Recruiting
Northwestern University
Chicago, Illinois, United States
Karan Dixit
Recruiting
University of Chicago Comprehensive Cancer Center
Chicago, Illinois, United States
Lauren Singer
Recruiting
Memorial Hospital East
Shiloh, Illinois, United States
Active, not recruiting
University of Kansas Clinical Research Center
Fairway, Kansas, United States
Tolga Tuncer
Recruiting
University of Kansas Cancer Center
Kansas City, Kansas, United States
Tolga Tuncer
Recruiting
University of Kansas Hospital-Westwood Cancer Center
Westwood, Kansas, United States
Tolga Tuncer
Recruiting
University of Kentucky/markey Cancer Center
Lexington, Kentucky, United States
John L. Villano
Recruiting
Siteman Cancer Center at Saint Peters Hospital
City of Saint Peters, Missouri, United States
Active, not recruiting
Siteman Cancer Center at West County Hospital
Creve Coeur, Missouri, United States
Active, not recruiting
Siteman Cancer Center at Christian Hospital
St Louis, Missouri, United States
Active, not recruiting
Siteman Cancer Center-South County
St Louis, Missouri, United States
Active, not recruiting
Washington University School of Medicine
St Louis, Missouri, United States
Active, not recruiting
Nyu Langone Hospital - Long Island
Mineola, New York, United States
Marissa Barbaro
Recruiting
Laura and Isaac Perlmutter Cancer Center at Nyu Langone
New York, New York, United States
Marissa Barbaro
Recruiting
Nyp/columbia University Medical Center/herbert Irving Comprehensive Cancer Center
New York, New York, United States
Aya Haggiagi
Recruiting
Carolinas Medical Center/levine Cancer Institute
Charlotte, North Carolina, United States
Ashley L. Sumrall
Recruiting
Wake Forest University Health Sciences
Winston-Salem, North Carolina, United States
Roy E. Strowd
Recruiting
Ohio State University Comprehensive Cancer Center
Columbus, Ohio, United States
Hamid R. Mohtashami
Recruiting
University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma, United States
James D. Battiste
Recruiting
Upmc Hillman Cancer Center
Pittsburgh, Pennsylvania, United States
Megan Mantica
Recruiting
Vanderbilt University/ingram Cancer Center
Nashville, Tennessee, United States
Alexander C. Mohler
Recruiting
Huntsman Cancer Institute/university of Utah
Salt Lake City, Utah, United States
Joe S. Mendez
Recruiting

3 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Triapine

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 30 Jul 2025
Primary completion: 30 Jun 2027
Completion: 30 Jun 2027
Last update posted: 21 Aug 2026
Registered enrollment: 30
Registry id: NCT06860594

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.