Clinical trialNCT07321652RecruitingPhase 3Interventional

Testing the Addition of Anti-Cancer Drug Sonrotoclax, to the Standard Treatment Zanubrutinib, for Previously Untreated CLL/SLL

SponsorAlliance for Clinical Trials in OncologyEnrollment466Chronic Lymphocytic LeukemiaSmall Lymphocytic Leukemia

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This phase III trial compares the effect of adding sonrotoclax to zanubrutinib versus zanubrutinib alone for the treatment of patients with untreated chronic lymphoblastic leukemia (CLL)/small lymphocytic lymphoma (SLL). Sonrotoclax is in a class of medications called B-cell lymphoma-2 (BCL-2) inhibitors. It may stop the growth of cancer cells by blocking Bcl-2, a protein needed for cancer cell survival. Zanubrutinib is in a class of medications called kinase inhibitors. It blocks a protein called BTK, which is present on B-cell (a type of white blood cells) cancers such as mantel cell lymphoma at abnormal levels. This may help keep cancer cells from growing and spreading. Giving sonrotoclax and zanubrutinib may be more effective than zanubrutinib alone for the treatment of untreated CLL/SLL.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Jennifer R Brown, MD
Alliance for Clinical Trials in Oncology
Study Chair
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

182 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Cedars-Sinai Medical Center
Los Angeles, California, United States
Justin M. Darrah
Recruiting
Kaiser Permanente - Panorama City
Panorama City, California, United States
Ashraf R. Aziz
Recruiting
Jupiter Medical Center
Jupiter, Florida, United States
Ryan H. Devine
Recruiting
Mount Sinai Medical Center
Miami Beach, Florida, United States
Jacqueline C. Barrientos
Recruiting
Saint Alphonsus Cancer Care Center-Boise
Boise, Idaho, United States
Christopher M. Reynolds
Recruiting
Saint Alphonsus Cancer Care Center-Caldwell
Caldwell, Idaho, United States
Christopher M. Reynolds
Recruiting
Kootenai Health - Coeur D'Alene
Coeur d'Alene, Idaho, United States
John M. Schallenkamp
Recruiting
Idaho Urologic Institute-Meridian
Meridian, Idaho, United States
Christopher M. Reynolds
Recruiting
Saint Alphonsus Cancer Care Center-Nampa
Nampa, Idaho, United States
Christopher M. Reynolds
Recruiting
Kootenai Clinic Cancer Services - Post Falls
Post Falls, Idaho, United States
John M. Schallenkamp
Recruiting
Kootenai Clinic Cancer Services - Sandpoint
Sandpoint, Idaho, United States
John M. Schallenkamp
Recruiting
Illinois Cancercare-Bloomington
Bloomington, Illinois, United States
Bryan A. Faller
Recruiting
Illinois Cancercare-Canton
Canton, Illinois, United States
Bryan A. Faller
Recruiting
Illinois Cancercare-Carthage
Carthage, Illinois, United States
Bryan A. Faller
Recruiting
Northwestern University
Chicago, Illinois, United States
Shuo Ma
Recruiting
University of Illinois
Chicago, Illinois, United States
Carlos Galvez
Recruiting
Carle at the Riverfront
Danville, Illinois, United States
Suparna Mantha
Recruiting
Cancer Care Specialists of Illinois - Decatur
Decatur, Illinois, United States
Bryan A. Faller
Recruiting
Decatur Memorial Hospital
Decatur, Illinois, United States
Bryan A. Faller
Recruiting
Illinois Cancercare-Dixon
Dixon, Illinois, United States
Bryan A. Faller
Recruiting
Carle Physician Group-Effingham
Effingham, Illinois, United States
Suparna Mantha
Recruiting
Illinois Cancercare-Eureka
Eureka, Illinois, United States
Bryan A. Faller
Recruiting
Illinois Cancercare-Galesburg
Galesburg, Illinois, United States
Bryan A. Faller
Recruiting
Illinois Cancercare-Kewanee Clinic
Kewanee, Illinois, United States
Bryan A. Faller
Recruiting
Illinois Cancercare-Macomb
Macomb, Illinois, United States
Bryan A. Faller
Recruiting
Carle Physician Group-Mattoon/charleston
Mattoon, Illinois, United States
Suparna Mantha
Recruiting
Carle Bromenn Medical Center
Normal, Illinois, United States
Suparna Mantha
Recruiting
Carle Cancer Institute Normal
Normal, Illinois, United States
Suparna Mantha
Recruiting
Cancer Care Center of O'Fallon
O'Fallon, Illinois, United States
Bryan A. Faller
Recruiting
Hshs Saint Elizabeth'S Hospital
O'Fallon, Illinois, United States
Bryan A. Faller
Recruiting
Illinois Cancercare-Ottawa Clinic
Ottawa, Illinois, United States
Bryan A. Faller
Recruiting
Illinois Cancercare-Pekin
Pekin, Illinois, United States
Bryan A. Faller
Recruiting
Illinois Cancercare-Peoria
Peoria, Illinois, United States
Bryan A. Faller
Recruiting
Illinois Cancercare-Peru
Peru, Illinois, United States
Bryan A. Faller
Recruiting
Illinois Cancercare-Princeton
Princeton, Illinois, United States
Bryan A. Faller
Recruiting
Memorial Hospital East
Shiloh, Illinois, United States
Dilan A. Patel
Recruiting
Southern Illinois University School of Medicine
Springfield, Illinois, United States
Bryan A. Faller
Recruiting
Springfield Clinic
Springfield, Illinois, United States
Bryan A. Faller
Recruiting
Springfield Memorial Hospital
Springfield, Illinois, United States
Bryan A. Faller
Recruiting
Carle Cancer Center
Urbana, Illinois, United States
Suparna Mantha
Recruiting

142 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

SonrotoclaxZanubrutinib →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 30 Apr 2026
Primary completion: 30 Sept 2028
Completion: 30 Sept 2038
Last update posted: 5 Aug 2026
Registered enrollment: 466
Registry id: NCT07321652

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.