Clinical trialNCT06917911RecruitingPhase 2Interventional

Testing the Addition of Venetoclax or Gemtuzumab Ozogamicin (GO) to Usual Treatment Regimen (Cytarabine and Daunorubicin, "7+3") for Core Binding Factor Acute Myeloid Leukemia (CBF-AML) to Improve Response (A MYELOMATCH Treatment Trial)

SponsorNational Cancer Institute (NCI)Enrollment162Core Binding Factor Acute Myeloid Leukemia

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This phase II MYELOMATCH treatment trial compares the effect of venetoclax to gemtuzumab ozogamicin, when given with cytarabine and daunorubicin ("7+3" regimen), for the treatment of patients with core binding factor acute myeloid leukemia (CBF-AML). Venetoclax is in a class of medications called B-cell lymphoma-2 (BCL-2) inhibitors. It may stop the growth of cancer cells by blocking Bcl-2, a protein needed for cancer cell survival. Gemtuzumab ozogamicin is a monoclonal antibody, called gemtuzumab, linked to an antitumor antibiotic drug, called ozogamicin. Gemtuzumab is a form of targeted therapy because it attaches to specific molecules (receptors) on the surface of cancer cells, known as CD33 receptors, and delivers ozogamicin to kill them. Chemotherapy drugs, such as cytarabine and daunorubicin work in different ways to stop the growth of cancer cells either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving venetoclax with cytarabine and daunorubicin may have fewer side effects and be as effective or better than the combination with gemtuzumab ozogamicin in treating patients with core binding factor AML.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Celalettin Ustun
Alliance for Clinical Trials in Oncology
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

40 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Memorial Hospital West
Pembroke Pines, Florida, United States
Yehuda E. Deutsch
Recruiting
Kootenai Health - Coeur D'Alene
Coeur d'Alene, Idaho, United States
John M. Schallenkamp
Recruiting
Kootenai Clinic Cancer Services - Post Falls
Post Falls, Idaho, United States
John M. Schallenkamp
Recruiting
Kootenai Clinic Cancer Services - Sandpoint
Sandpoint, Idaho, United States
John M. Schallenkamp
Recruiting
Northwestern University
Chicago, Illinois, United States
Yuchen Liu
Recruiting
University of Kansas Clinical Research Center
Fairway, Kansas, United States
Jesus Gonzalez Lugo
Recruiting
University of Kansas Cancer Center
Kansas City, Kansas, United States
Jesus Gonzalez Lugo
Recruiting
University of Kansas Hospital-Indian Creek Campus
Overland Park, Kansas, United States
Jesus Gonzalez Lugo
Recruiting
University of Kansas Hospital-Westwood Cancer Center
Westwood, Kansas, United States
Jesus Gonzalez Lugo
Recruiting
University of Kentucky/markey Cancer Center
Lexington, Kentucky, United States
Fevzi Yalniz
Recruiting
the James Graham Brown Cancer Center at University of Louisville
Louisville, Kentucky, United States
Mohamed M. Hegazi
Recruiting
Uofl Health Medical Center Northeast
Louisville, Kentucky, United States
Mohamed M. Hegazi
Recruiting
Tufts Medical Center
Boston, Massachusetts, United States
Andreas K. Klein
Recruiting
Trinity Health Iha Medical Group Hematology Oncology - Brighton
Brighton, Michigan, United States
Tareq Al baghdadi
Recruiting
Trinity Health Iha Medical Group Hematology Oncology - Canton
Canton, Michigan, United States
Tareq Al baghdadi
Recruiting
Trinity Health Iha Medical Group Hematology Oncology - Chelsea Hospital
Chelsea, Michigan, United States
Tareq Al baghdadi
Recruiting
Trinity Health Saint Mary Mercy Livonia Hospital
Livonia, Michigan, United States
Tareq Al baghdadi
Recruiting
Trinity Health Saint Joseph Mercy Oakland Hospital
Pontiac, Michigan, United States
Tareq Al baghdadi
Recruiting
Trinity Health Iha Medical Group Hematology Oncology Ann Arbor Campus
Ypsilanti, Michigan, United States
Tareq Al baghdadi
Recruiting
Baptist Memorial Hospital and Cancer Center-Golden Triangle
Columbus, Mississippi, United States
Salil Goorha
Recruiting
Baptist Cancer Center-Grenada
Grenada, Mississippi, United States
Salil Goorha
Recruiting
Baptist Memorial Hospital and Cancer Center-Union County
New Albany, Mississippi, United States
Salil Goorha
Recruiting
Baptist Memorial Hospital and Cancer Center-Oxford
Oxford, Mississippi, United States
Salil Goorha
Recruiting
Baptist Memorial Hospital and Cancer Center-Desoto
Southhaven, Mississippi, United States
Salil Goorha
Recruiting
Billings Clinic Cancer Center
Billings, Montana, United States
John M. Schallenkamp
Recruiting
Bozeman Health Deaconess Hospital
Bozeman, Montana, United States
John M. Schallenkamp
Recruiting
Benefis Sletten Cancer Institute
Great Falls, Montana, United States
John M. Schallenkamp
Recruiting
Community Medical Center
Missoula, Montana, United States
John M. Schallenkamp
Recruiting
University of Rochester
Rochester, New York, United States
Bassil Botros
Recruiting
Montefiore Medical Center - Moses Campus
The Bronx, New York, United States
Ioannis Mantzaris
Recruiting
Prisma Health Cancer Institute - Spartanburg
Boiling Springs, South Carolina, United States
Suzanne R. Fanning
Recruiting
Prisma Health Cancer Institute - Easley
Easley, South Carolina, United States
Suzanne R. Fanning
Recruiting
Prisma Health Cancer Institute - Butternut
Greenville, South Carolina, United States
Suzanne R. Fanning
Recruiting
Prisma Health Cancer Institute - Eastside
Greenville, South Carolina, United States
Suzanne R. Fanning
Recruiting
Prisma Health Cancer Institute - Faris
Greenville, South Carolina, United States
Suzanne R. Fanning
Recruiting
Prisma Health Cancer Institute - Greer
Greer, South Carolina, United States
Suzanne R. Fanning
Recruiting
Prisma Health Cancer Institute - Seneca
Seneca, South Carolina, United States
Suzanne R. Fanning
Recruiting
Baptist Memorial Hospital and Cancer Center-Collierville
Collierville, Tennessee, United States
Salil Goorha
Recruiting
Baptist Memorial Hospital and Cancer Center-Memphis
Memphis, Tennessee, United States
Salil Goorha
Recruiting
Gundersen Lutheran Medical Center
La Crosse, Wisconsin, United States
Michael O. Ojelabi
Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Cytarabine →Daunorubicin →Gemtuzumab ozogamicin →Venetoclax →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 2 Feb 2027
Primary completion: 25 Nov 2027
Completion: 25 Nov 2027
Last update posted: 21 Aug 2026
Registered enrollment: 162
Registry id: NCT06917911

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.