Clinical trialNCT06317649RecruitingPhase 2Interventional

Venetoclax and HMA Treatment of Older and Unfit Adults With FLT3 Mutated Acute Myeloid Leukemia (AML) (A MyeloMATCH Treatment Trial)

SponsorNational Cancer Institute (NCI)Enrollment147Acute Myeloid Leukemia

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This phase II MyeloMATCH treatment trial compares the usual treatment of azacitidine and venetoclax to the combination treatment of azacitidine, venetoclax and gilteritinib in treating older and unfit patients with acute myeloid leukemia and FLT3 mutations. Azacitidine is a drug that is absorbed into DNA and leads to the activation of cancer suppressor genes, which are genes that help control cell growth. Venetoclax is in a class of medications called B-cell lymphoma-2 (BCL-2) inhibitors. It may stop the growth of cancer cells by blocking Bcl-2, a protein needed for cancer cell survival. Gilteritinib is in a class of medications called kinase inhibitors. It works by blocking the action of a certain naturally occurring substance that may be needed to help cancer cells multiply. This study may help doctors find out if these different approaches are better than the usual approaches. To decide if they are better, the study doctors are looking to see if the study drugs lead to a higher percentage of patients achieving a deeper remission compared to the usual approach.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Jessica K Altman
ECOG-ACRIN Cancer Research Group
Principal InvestigatorKOL profile →
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

227 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Puerto Rico

Centro Comprensivo de Cancer de Upr
San Juan, Puerto Rico
Luis J. Santos Reyes
Recruiting
San Juan City Hospital
San Juan, Puerto Rico
Luis J. Santos Reyes
Recruiting

United States

University of Alabama at Birmingham Cancer Center
Birmingham, Alabama, United States
Razan Mohty
Recruiting
Banner University Medical Center - Tucson
Tucson, Arizona, United States
Sharad Khurana
Recruiting
University of Arizona Cancer Center-North Campus
Tucson, Arizona, United States
Sharad Khurana
Recruiting
University of Arkansas for Medical Sciences
Little Rock, Arkansas, United States
Ankur Varma
Recruiting
Alta Bates Summit Medical Center-Herrick Campus
Berkeley, California, United States
Active, not recruiting
Kaiser Permanente Dublin
Dublin, California, United States
Faisal N. Cheema
Recruiting
Kaiser Permanente-Fremont
Fremont, California, United States
Faisal N. Cheema
Recruiting
Kaiser Permanente Fresno Orchard Plaza
Fresno, California, United States
Faisal N. Cheema
Recruiting
Kaiser Permanente-Fresno
Fresno, California, United States
Faisal N. Cheema
Recruiting
Cedars-Sinai Medical Center
Los Angeles, California, United States
Noah M. Merin
Recruiting
Kaiser Permanente- Modesto Mob Ii
Modesto, California, United States
Faisal N. Cheema
Recruiting
Kaiser Permanente-Modesto
Modesto, California, United States
Faisal N. Cheema
Recruiting
Kaiser Permanente-Oakland
Oakland, California, United States
Faisal N. Cheema
Recruiting
Kaiser Permanente-Roseville
Roseville, California, United States
Faisal N. Cheema
Recruiting
Kaiser Permanente Downtown Commons
Sacramento, California, United States
Faisal N. Cheema
Recruiting
Kaiser Permanente-South Sacramento
Sacramento, California, United States
Faisal N. Cheema
Recruiting
University of California Davis Comprehensive Cancer Center
Sacramento, California, United States
Brian A. Jonas
Recruiting
Kaiser Permanente-San Francisco
San Francisco, California, United States
Faisal N. Cheema
Recruiting
Ucsf Medical Center-Parnassus
San Francisco, California, United States
Timothy Ferng
Recruiting
Kaiser Permanente-Santa Teresa-San Jose
San Jose, California, United States
Faisal N. Cheema
Recruiting
Kaiser Permanente San Leandro
San Leandro, California, United States
Faisal N. Cheema
Recruiting
Mills Health Center
San Mateo, California, United States
Active, not recruiting
Kaiser San Rafael-Gallinas
San Rafael, California, United States
Faisal N. Cheema
Recruiting
Kaiser Permanente Medical Center - Santa Clara
Santa Clara, California, United States
Faisal N. Cheema
Recruiting
Kaiser Permanente-Santa Rosa
Santa Rosa, California, United States
Faisal N. Cheema
Recruiting
Kaiser Permanente-South San Francisco
South San Francisco, California, United States
Faisal N. Cheema
Recruiting
Kaiser Permanente-Vallejo
Vallejo, California, United States
Faisal N. Cheema
Recruiting
Kaiser Permanente-Walnut Creek
Walnut Creek, California, United States
Faisal N. Cheema
Recruiting
Yale University
New Haven, Connecticut, United States
Jan P. Bewersdorf
Recruiting
Veterans Affairs Connecticut Healthcare System-West Haven Campus
West Haven, Connecticut, United States
Alexander Pine
Recruiting
Uf Health Cancer Institute - Gainesville
Gainesville, Florida, United States
Dina G. Khalaf
Recruiting
Miami Cancer Institute
Miami, Florida, United States
Firas El Chaer
Recruiting
Phoebe Putney Memorial Hospital
Albany, Georgia, United States
Vamsi Kota
Recruiting
Augusta University Medical Center
Augusta, Georgia, United States
Vamsi Kota
Recruiting
Hawaii Cancer Care Inc - Waterfront Plaza
Honolulu, Hawaii, United States
Craig S. Boddy
Recruiting
Kaiser Permanente Moanalua Medical Center
Honolulu, Hawaii, United States
Faisal N. Cheema
Recruiting
Straub Clinic and Hospital
Honolulu, Hawaii, United States
Craig S. Boddy
Recruiting
Hawaii Cancer Care - Westridge
‘Aiea, Hawaii, United States
Craig S. Boddy
Recruiting

187 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Azacitidine →Gilteritinib →Venetoclax →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 27 Sept 2024
Primary completion: 15 May 2029
Completion: 15 May 2029
Last update posted: 19 Aug 2026
Registered enrollment: 147
Registry id: NCT06317649

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.