Clinical trialNCT06937099RecruitingPhase 3Interventional

Mirikizumab and Tirzepatide Administered in Adult Participants With Moderately to Severely Active Crohn's Disease and Obesity or Overweight

SponsorEli Lilly and CompanyEnrollment290Crohn's DiseaseObesity or Overweight

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The main purpose of this study is to evaluate the efficacy and safety of mirikizumab and placebo compared with mirikizumab and concomitantly administered tirzepatide in adult participants with moderately to severely active CD and obesity, or overweight. The maximum duration of this study is up to 61 weeks.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 8 AM - 8 PM Eastern time (UTC/GMT - 5 hours, EST)
Eli Lilly and Company
Study Director
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

184 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Austria

Medizinische Universität Graz
Graz, Austria
Christoph Hoegenauer
Recruiting
Medizinische Universitaet Innsbruck
Innsbruck, Austria
Robert Koch
Recruiting
Medizinische Universität Wien
Vienna, Austria
Walter Reinisch
Recruiting

Belgium

Azorg Campus Aalst-Moorselbaan
Aalst, Belgium
Stijn Vanden Branden
Recruiting
Université Libre de Bruxelles - Hôpital Erasme
Brussels, Belgium
Denis Franchimont
Recruiting
Az Groeninge Campus Kennedylaan
Kortrijk, Belgium
Wouter Van Moerkercke
Recruiting
Uz Leuven
Leuven, Belgium
João Guedelha Sabino
Recruiting
Centre Hospitalier Universitaire de Liège - Domaine Universitaire Du Sart Tilman
Liège, Belgium
Edouard Louis
Recruiting
Clinical Chc Montlégia
Liège, Belgium
Arnaud Colard
Recruiting

Brazil

Newdata Clinical Research - Aracaju
Aracaju, Brazil
Alex Callado França
Recruiting
L2ip - Instituto de Pesquisas Clínicas
Brasília, Brazil
Luciana Teixeira de Campos
Recruiting
Loema Instituto de Pesquisa Clinica
Campinas, Brazil
Joaquim Simoes Neto
Recruiting
Fundação Universidade de Caxias Do Sul (fucs)
Caxias do Sul, Brazil
Eduardo Brambilla
Recruiting
Centro Digestivo de Curitiba
Curitiba, Brazil
Odery Ramos Júnior
Recruiting
Galileo Medical Research
Juiz de Fora, Brazil
Julio Chebli
Recruiting
Hospital de Clinicas de Porto Alegre
Porto Alegre, Brazil
Luciana Harlacher
Recruiting
Hospital de Clínicas de Ribeirão Preto
Ribeirão Preto, Brazil
Rogerio Parra
Recruiting
Cliagen Clínica de Atenção Em Gastroenterologia, Especialidades E Nutrição
Salvador, Brazil
Genoile Silva
Recruiting
Pesquisare Saude
Santo André, Brazil
ALEXANDER DE SA ROLIM
Recruiting
Cepic - Centro Paulista de Investigação Clínica
São Paulo, Brazil
Renata Lamanna
Recruiting
Cpquali Pesquisa Clínica
São Paulo, Brazil
Alexandre de Sousa Carlos
Recruiting
Clínica Hepatogastro Jk
São Paulo, Brazil
Rodrigo Andrey Rocco
Recruiting
Cedoes
Vitória, Brazil
Felipe Ferreira
Recruiting
Integral Pesquisa E Ensino
Votuporanga, Brazil
HERLON VALÉRIO
Recruiting

Bulgaria

University Hospital "st. Ivan Rilski"
Gorna Oryahovitsa, Bulgaria
Ilko Kosturkov
Recruiting

Canada

Gastroenterology and Internal Medicine Research Institute
Edmonton, Canada
Allen Lim
Not, yet, recruiting
London Digestive Disease Institute
London, Canada
Vipul Jairath
Recruiting
London Health Sciences Centre
London, Canada
Terry Ponich
Recruiting
Clinique Imd
Montreal, Canada
Waqqas Afif
Recruiting
the Ottawa Hospital - General Campus
Ottawa, Canada
Jeffrey McCurdy
Not, yet, recruiting
(g.I.R.I.) Gi Research Institute Foundation
Vancouver, Canada
Greg Rosenfeld
Recruiting
Vancouver General Hospital
Vancouver, Canada
Sundeep Singh
Not, yet, recruiting

Czechia

Surgal Clinic
Brno, Czechia
Jan Ulbrych
Recruiting
Gastroenterologie
Hradec Králové, Czechia
Milan Siroky
Recruiting
Endoart
Ostrava, Czechia
Radka Koskova
Recruiting
Iscare Klinické Centrum
Prague, Czechia
Milan Lukas
Recruiting
Restrial Gastroendo S.R.O
Prague, Czechia
Ludek Hrdlicka
Recruiting
Masarykova Nemocnice V Usti Nad Labem
Ústí nad Labem, Czechia
Michal Tichy
Recruiting

Denmark

Aarhus Universitetshospital, Skejby
Aarhus, Denmark
Anders Dige
Recruiting
Herlev and Gentofte Hospital
Copenhagen, Denmark
Jacob Bjerrum
Recruiting

144 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Mirikizumab →PlaceboTirzepatide →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 26 Jun 2025
Primary completion: 31 May 2028
Completion: 31 May 2028
Last update posted: 21 Aug 2026
Registered enrollment: 290
Registry id: NCT06937099

Cross-registrations

EU-CTR / CTIS (EudraCT)2024-520210-21-00

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.