Clinical trialNCT07042295RecruitingPhase 2Interventional

Treatment With Amivantamab and Hyaluronidase or Cetuximab for Advanced Skin Cancer in People With a Weakened Immune System

SponsorNational Cancer Institute (NCI)Enrollment86Locally Recurrent Skin Squamous Cell CarcinomaMetastatic Skin Squamous Cell Carcinoma

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This phase II trial compares the effect of amivantamab and hyaluronidase to cetuximab for the treatment of skin (cutaneous) squamous cell carcinoma that has come back after a period of improvement and has not spread to other parts of the body (locally recurrent) or that has spread from where it first started (primary site) to other places in the body (metastatic). Amivantamab is a monoclonal antibody that may interfere with the ability of tumor cells to grow and spread. A monoclonal antibody is a type of protein that can bind to certain targets in the body, such as molecules that cause the body to make an immune response (antigens). Hyaluronidase is an endoglycosidase. It helps to keep amivantamab in the body longer, so that the medications will have a greater effect. Cetuximab is in a class of medications called monoclonal antibodies. It binds to a protein called EGFR, which is found on some types of cancer cells. This may help keep cancer cells from growing. Giving amivantamab and hyaluronidase may be as effective as cetuximab for the treatment of locally recurrent or metastatic cutaneous squamous cell carcinoma.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Paul L Swiecicki
SWOG Cancer Research Network
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

51 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

University of Alabama at Birmingham Cancer Center
Birmingham, Alabama, United States
Mehran Yusuf
Recruiting
Banner Md Anderson Cancer Center
Gilbert, Arizona, United States
Saba H. Radhi
Recruiting
Uc San Diego Moores Cancer Center
La Jolla, California, United States
Soo Park
Recruiting
Usc / Norris Comprehensive Cancer Center
Los Angeles, California, United States
Gino K. In
Recruiting
Uchealth University of Colorado Hospital
Aurora, Colorado, United States
Sapna P. Patel
Recruiting
Yale University
New Haven, Connecticut, United States
Barbara A. Burtness
Recruiting
Smilow Cancer Hospital Care Center-Trumbull
Trumbull, Connecticut, United States
Barbara A. Burtness
Recruiting
Smilow Cancer Hospital Care Center - Waterford
Waterford, Connecticut, United States
Barbara A. Burtness
Recruiting
Um Sylvester Comprehensive Cancer Center at Coral Gables
Coral Gables, Florida, United States
Leonel F. Hernandez-Aya
Recruiting
Um Sylvester Comprehensive Cancer Center at Coral Springs
Coral Springs, Florida, United States
Leonel F. Hernandez-Aya
Recruiting
Um Sylvester Comprehensive Cancer Center at Deerfield Beach
Deerfield Beach, Florida, United States
Leonel F. Hernandez-Aya
Recruiting
Um Sylvester Comprehensive Cancer Center at Doral
Doral, Florida, United States
Leonel F. Hernandez-Aya
Recruiting
Um Sylvester Comprehensive Cancer Center at Kendall
Miami, Florida, United States
Leonel F. Hernandez-Aya
Recruiting
University of Miami Miller School of Medicine-Sylvester Cancer Center
Miami, Florida, United States
Leonel F. Hernandez-Aya
Recruiting
University of Miami Sylvester Comprehensive Cancer Center at Sole Mia
North Miami, Florida, United States
Leonel F. Hernandez-Aya
Recruiting
Um Sylvester Comprehensive Cancer Center at Plantation
Plantation, Florida, United States
Leonel F. Hernandez-Aya
Recruiting
University of Chicago Comprehensive Cancer Center
Chicago, Illinois, United States
Noura Choudhury
Recruiting
Carle at the Riverfront
Danville, Illinois, United States
Suparna Mantha
Recruiting
Carle Physician Group-Effingham
Effingham, Illinois, United States
Suparna Mantha
Recruiting
Ingalls Memorial Hospital
Harvey, Illinois, United States
Kimberly R. Kruczek
Recruiting
Carle Physician Group-Mattoon/charleston
Mattoon, Illinois, United States
Suparna Mantha
Recruiting
Uc Comprehensive Cancer Center at Silver Cross
New Lenox, Illinois, United States
Noura Choudhury
Recruiting
Carle Bromenn Medical Center
Normal, Illinois, United States
Suparna Mantha
Recruiting
Carle Cancer Institute Normal
Normal, Illinois, United States
Suparna Mantha
Recruiting
University of Chicago Medicine-Orland Park
Orland Park, Illinois, United States
Noura Choudhury
Recruiting
Carle Cancer Center
Urbana, Illinois, United States
Suparna Mantha
Recruiting
Uchicago Medicine Northwest Indiana
Crown Point, Indiana, United States
Noura Choudhury
Recruiting
University of Michigan Rogel Cancer Center
Ann Arbor, Michigan, United States
Paul L. Swiecicki
Recruiting
Henry Ford Hospital
Detroit, Michigan, United States
Amy M. Weise
Recruiting
Memorial Sloan Kettering Basking Ridge
Basking Ridge, New Jersey, United States
Lara A. Dunn
Recruiting
Memorial Sloan Kettering Monmouth
Middletown, New Jersey, United States
Lara A. Dunn
Recruiting
Memorial Sloan Kettering Bergen
Montvale, New Jersey, United States
Lara A. Dunn
Recruiting
Memorial Sloan Kettering Commack
Commack, New York, United States
Lara A. Dunn
Recruiting
Memorial Sloan Kettering Westchester
Harrison, New York, United States
Lara A. Dunn
Recruiting
Memorial Sloan Kettering Cancer Center
New York, New York, United States
Lara A. Dunn
Recruiting
Memorial Sloan Kettering Nassau
Uniondale, New York, United States
Lara A. Dunn
Recruiting
Uh Seidman Cancer Center at Uh Avon Health Center
Avon, Ohio, United States
Ankit Mangla
Recruiting
Uhhs-Chagrin Highlands Medical Center
Beachwood, Ohio, United States
Ankit Mangla
Recruiting
University of Cincinnati Cancer Center-Uc Medical Center
Cincinnati, Ohio, United States
Rekha T. Chaudhary
Recruiting
Case Western Reserve University
Cleveland, Ohio, United States
Ankit Mangla
Recruiting

11 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Amivantamab and Recombinant Human HyaluronidaseCetuximab →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 23 Mar 2026
Primary completion: 28 Feb 2029
Completion: 28 Feb 2029
Last update posted: 20 Aug 2026
Registered enrollment: 86
Registry id: NCT07042295

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.