Clinical trialNCT07195734RecruitingPhase 2Interventional

Testing the Addition of Chemotherapy or Chemo-Immunotherapy to the Usual Surgery for Advanced Head and Neck Cancer

SponsorNational Cancer Institute (NCI)Enrollment180Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8Locally Recurrent Head and Neck Squamous Cell CarcinomaLocally Recurrent Hypopharyngeal Squamous Cell CarcinomaLocally Recurrent Laryngeal Squamous Cell CarcinomaLocally Recurrent Oral Cavity Squamous Cell Carcinoma+12 more conditions

View the registry record on ClinicalTrials.gov

Summary

The registered summary isn't in our current data snapshot. Read it on the ClinicalTrials.gov record ↗. Why? →

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Nabil F Saba
NRG Oncology
Principal InvestigatorKOL profile →
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

90 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Banner University Medical Center - Tucson
Tucson, Arizona, United States
Ricklie A. Julian
Recruiting
University of Arizona Cancer Center-North Campus
Tucson, Arizona, United States
Ricklie A. Julian
Recruiting
Usc / Norris Comprehensive Cancer Center
Los Angeles, California, United States
Jacob S. Thomas
Recruiting
Sutter Medical Center Sacramento
Sacramento, California, United States
Christopher U. Jones
Recruiting
University of California Davis Comprehensive Cancer Center
Sacramento, California, United States
Andrew C. Birkeland
Recruiting
Emory Proton Therapy Center
Atlanta, Georgia, United States
Jennifer Gross
Recruiting
Emory University Hospital Midtown
Atlanta, Georgia, United States
Jennifer Gross
Recruiting
Rush Md Anderson Cancer Center
Chicago, Illinois, United States
Michael J. Jelinek
Recruiting
Rush Md Anderson Cancer Center at Rush Lisle
Lisle, Illinois, United States
Michael J. Jelinek
Recruiting
Northwestern Medicine Orland Park
Orland Park, Illinois, United States
Jochen H. Lorch
Recruiting
Memorial Hospital East
Shiloh, Illinois, United States
Brendan J. Knapp
Recruiting
Ui Health Care Mission Cancer and Blood - Ankeny Clinic
Ankeny, Iowa, United States
Seema Harichand-Herdt
Recruiting
Ui Health Care Mission Cancer and Blood - West Des Moines Clinic
Clive, Iowa, United States
Seema Harichand-Herdt
Recruiting
Methodist Jennie Edmundson Hospital
Council Bluffs, Iowa, United States
Suspended
Broadlawns Medical Center
Des Moines, Iowa, United States
Seema Harichand-Herdt
Recruiting
Iowa Methodist Medical Center
Des Moines, Iowa, United States
Seema Harichand-Herdt
Recruiting
Mercy Medical Center - Des Moines
Des Moines, Iowa, United States
Richard L. Deming
Recruiting
Ui Health Care Mission Cancer and Blood - Des Moines Clinic
Des Moines, Iowa, United States
Seema Harichand-Herdt
Recruiting
Ui Health Care Mission Cancer and Blood - Laurel Clinic
Des Moines, Iowa, United States
Seema Harichand-Herdt
Recruiting
Ui Health Care Mission Cancer and Blood - Waukee Clinic
Waukee, Iowa, United States
Seema Harichand-Herdt
Recruiting
University of Kansas Cancer Center
Kansas City, Kansas, United States
Omar A. Karadaghy
Recruiting
University of Kansas Cancer Center-Overland Park
Overland Park, Kansas, United States
Omar A. Karadaghy
Recruiting
University of Kansas Hospital-Westwood Cancer Center
Westwood, Kansas, United States
Omar A. Karadaghy
Recruiting
Lsu Health Baton Rouge-North Clinic
Baton Rouge, Louisiana, United States
Sagar G. Kansara
Recruiting
Our Lady of the Lake Physician Group
Baton Rouge, Louisiana, United States
Sagar G. Kansara
Recruiting
Lafayette Family Cancer Center-Emmc
Brewer, Maine, United States
Sarah J. Sinclair
Recruiting
University of Michigan Rogel Cancer Center
Ann Arbor, Michigan, United States
Paul L. Swiecicki
Recruiting
University of Michigan - Brighton Center for Specialty Care
Brighton, Michigan, United States
Paul L. Swiecicki
Recruiting
Henry Ford Hospital
Detroit, Michigan, United States
Samantha H. Tam
Recruiting
Siteman Cancer Center at Saint Peters Hospital
City of Saint Peters, Missouri, United States
Brendan J. Knapp
Recruiting
Siteman Cancer Center at West County Hospital
Creve Coeur, Missouri, United States
Brendan J. Knapp
Recruiting
University of Kansas Cancer Center - Briarcliff
Kansas City, Missouri, United States
Omar A. Karadaghy
Recruiting
University of Kansas Cancer Center - North
Kansas City, Missouri, United States
Omar A. Karadaghy
Recruiting
University of Kansas Cancer Center - Lee'S Summit
Lee's Summit, Missouri, United States
Omar A. Karadaghy
Recruiting
Siteman Cancer Center at Christian Hospital
St Louis, Missouri, United States
Brendan J. Knapp
Recruiting
Siteman Cancer Center-South County
St Louis, Missouri, United States
Brendan J. Knapp
Recruiting
Washington University School of Medicine
St Louis, Missouri, United States
Brendan J. Knapp
Recruiting
Nebraska Cancer Specialists/oncology Hematology West Pc - Mecc
Omaha, Nebraska, United States
Yungpo B. Su
Recruiting
Nebraska Methodist Hospital
Omaha, Nebraska, United States
Yungpo B. Su
Recruiting
Cooper Hospital University Medical Center
Camden, New Jersey, United States
Brian Swendseid
Recruiting

50 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study — it may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 24 Apr 2026
Primary completion: 1 Feb 2033
Completion: 1 Feb 2033
Last update posted: 10 Jul 2026
Registered enrollment: 180
Registry id: NCT07195734

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 12 Jul 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.