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Clinical trialNCT07126158RecruitingPhase 2Interventional

Stereotactic Body Radiotherapy Plus FAK and RAF/MEK Inhibition in Advanced Pancreatic Adenocarcinoma

SponsorWashington University School of MedicineEnrollment36Cancer of the PancreasPancreas CancerPancreatic AdenocarcinomaPancreatic Cancer
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

Advanced pancreatic cancer patients receiving treatment of adaptive stereotactic body radiotherapy (SBRT) with concurrent and adjuvant defactinib plus avutometinib will have increased progression-free survival (PFS) compared to historical PFS rates for patients receiving adaptive SBRT alone.

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

  • Patrick Grierson, M.D., Ph.D.

    Washington University School of Medicine

    Principal Investigator

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

1 registered facility, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States
  • Washington University School of Medicine

    St Louis, Missouri, United States

    Adeel Khan, M.D.Benjamin Tan, M.D.Carl DeSelm, M.D., Ph.D.Dan Mullady, M.D.David DeNardo, Ph.D.Dominic Sanford, M.D.Esther Lu, Ph.D.Gabriel Lang, M.D.Julie Schwarz, M.D., Ph.D.Kian-Huat Lim, M.D., Ph.D.Koushik Das, M.D.Liang I-Kang, M.D., Ph.D.Majella Doyle, M.D.Natasha Leigh-Matijakovich, M.D.Nikolaos Trikalinos, M.D.Olivia Aranha, M.D.Pamela Samson, M.D.Patrick Grierson, M.D., Ph.D.Rama Suresh, M.D.Roheena Panni, M.D., Ph.D.Vladimir Khushnir, M.D.William Chapman, M.D.
    Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
10 Apr 2026
Primary completion
30 Apr 2030
Completion
30 Apr 2030
Last update posted
15 Apr 2026
Registered enrollment
36
Registry id
NCT07126158

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.