Clinical trialNCT06900595RecruitingPhase 2Interventional

Testing the Addition of an Anti-Cancer Drug, Cabozantinib to the Immunotherapy Drug Cemiplimab (REGN2810), in Adolescents and Adults With Advanced Adrenocortical Cancer

SponsorNational Cancer Institute (NCI)Enrollment48Locally Advanced Adrenal Cortical CarcinomaMetastatic Adrenal Cortical CarcinomaRecurrent Adrenal Cortical CarcinomaStage III Adrenal Cortical Carcinoma AJCC v8Stage IV Adrenal Cortical Carcinoma AJCC v8Unresectable Adrenal Cortical Carcinoma

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This phase II trial compares the effect of giving cabozantinib with or without cemiplimab in patients with adrenocortical cancer that has spread to nearby tissue or lymph nodes (locally advanced), and that cannot be removed by surgery (unresectable) or that has come back after a period of improvement (recurrent) or that has spread from where it first started (primary site) to other places in the body (metastatic). Cabozantinib is in a class of medications called tyrosine kinase inhibitors. It works by blocking the action of an abnormal protein that signals cancer cells to multiply, which may help keep cancer cells from growing. Immunotherapy with monoclonal antibodies, such as cemiplimab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Giving cabozantinib with cemiplimab may kill more tumor cells in patients with locally advanced unresectable or recurrent/metastatic adrenocortical cancer.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Bhavana Konda
Alliance for Clinical Trials in Oncology
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

79 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Uc San Diego Moores Cancer Center
La Jolla, California, United States
Yu-Wei Chen
Recruiting
Valley Children'S Hospital
Madera, California, United States
Ruetima Titapiwatanakun
Recruiting
Uchealth University of Colorado Hospital
Aurora, Colorado, United States
Laura Graham
Recruiting
Mayo Clinic in Florida
Jacksonville, Florida, United States
Julie E. Hallanger Johnson
Recruiting
Lurie Children'S Hospital-Chicago
Chicago, Illinois, United States
Elizabeth A. Sokol
Recruiting
Northwestern University
Chicago, Illinois, United States
Mary F. Mulcahy
Recruiting
Carle at the Riverfront
Danville, Illinois, United States
Priyank P. Patel
Recruiting
Northwestern Medicine Cancer Center Kishwaukee
DeKalb, Illinois, United States
Mary F. Mulcahy
Recruiting
Carle Physician Group-Effingham
Effingham, Illinois, United States
Priyank P. Patel
Recruiting
Northwestern Medicine Cancer Center Delnor
Geneva, Illinois, United States
Mary F. Mulcahy
Recruiting
Northwestern Medicine Glenview Outpatient Center
Glenview, Illinois, United States
Mary F. Mulcahy
Recruiting
Northwestern Medicine Grayslake Outpatient Center
Grayslake, Illinois, United States
Mary F. Mulcahy
Recruiting
Northwestern Medicine Lake Forest Hospital
Lake Forest, Illinois, United States
Mary F. Mulcahy
Recruiting
Carle Physician Group-Mattoon/charleston
Mattoon, Illinois, United States
Priyank P. Patel
Recruiting
Carle Bromenn Medical Center
Normal, Illinois, United States
Priyank P. Patel
Recruiting
Carle Cancer Institute Normal
Normal, Illinois, United States
Priyank P. Patel
Recruiting
Northwestern Medicine Oak Brook
Oak Brook, Illinois, United States
Mary F. Mulcahy
Recruiting
Northwestern Medicine Orland Park
Orland Park, Illinois, United States
Mary F. Mulcahy
Recruiting
Memorial Hospital East
Shiloh, Illinois, United States
Nikolaos Trikalinos
Recruiting
Carle Cancer Center
Urbana, Illinois, United States
Priyank P. Patel
Recruiting
Northwestern Medicine Cancer Center Warrenville
Warrenville, Illinois, United States
Mary F. Mulcahy
Recruiting
Ui Health Care Mission Cancer and Blood - Ankeny Clinic
Ankeny, Iowa, United States
Seema Harichand-Herdt
Recruiting
Saint Anthony Regional Hospital
Carroll, Iowa, United States
Seema Harichand-Herdt
Recruiting
Ui Health Care Mission Cancer and Blood - West Des Moines Clinic
Clive, Iowa, United States
Seema Harichand-Herdt
Recruiting
Broadlawns Medical Center
Des Moines, Iowa, United States
Seema Harichand-Herdt
Recruiting
Iowa Methodist Medical Center
Des Moines, Iowa, United States
Seema Harichand-Herdt
Recruiting
Mercy Medical Center - Des Moines
Des Moines, Iowa, United States
Richard L. Deming
Recruiting
Ui Health Care Mission Cancer and Blood - Des Moines Clinic
Des Moines, Iowa, United States
Seema Harichand-Herdt
Recruiting
Ui Health Care Mission Cancer and Blood - Laurel Clinic
Des Moines, Iowa, United States
Seema Harichand-Herdt
Recruiting
Ui Healthcare Mission Cancer and Blood - Fort Dodge
Fort Dodge, Iowa, United States
Seema Harichand-Herdt
Recruiting
Ui Health Care Mission Cancer and Blood - Waukee Clinic
Waukee, Iowa, United States
Seema Harichand-Herdt
Recruiting
Dana-Farber Cancer Institute
Boston, Massachusetts, United States
Stephanie A. Berg
Recruiting
University of Michigan Rogel Cancer Center
Ann Arbor, Michigan, United States
Francis P. Worden →
Recruiting
Mayo Clinic in Rochester
Rochester, Minnesota, United States
Julie E. Hallanger Johnson
Recruiting
Siteman Cancer Center at Saint Peters Hospital
City of Saint Peters, Missouri, United States
Nikolaos Trikalinos
Recruiting
Siteman Cancer Center at West County Hospital
Creve Coeur, Missouri, United States
Nikolaos Trikalinos
Recruiting
Children'S Mercy Hospitals and Clinics
Kansas City, Missouri, United States
Keith J. August
Recruiting
Coxhealth South Hospital
Springfield, Missouri, United States
Jay W. Carlson
Recruiting
Siteman Cancer Center at Christian Hospital
St Louis, Missouri, United States
Nikolaos Trikalinos
Recruiting
Siteman Cancer Center-South County
St Louis, Missouri, United States
Nikolaos Trikalinos
Recruiting

39 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Cabozantinib →Cemiplimab →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 22 Feb 2026
Primary completion: 2 Jun 2029
Completion: 2 Jun 2029
Last update posted: 7 Aug 2026
Registered enrollment: 48
Registry id: NCT06900595

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.