Clinical trialNCT07221188RecruitingPhase 3Interventional

A Clinical Study to Investigate the Safety and Tolerability of Efimosfermin Alfa Injection in Participants With Known or Suspected F2- or F3-stage MASH

SponsorGlaxoSmithKlineEnrollment1,250Non-alcoholic Fatty Liver Disease

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This study will evaluate the safety and tolerability of Efimosfermin Alfa for participants with known or suspected MASH with fibrosis consistent with stage F2 or F3.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

GSK Clinical Trials
GlaxoSmithKline
Study Director
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

53 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Hong Kong

Gsk Investigational Site
Pokfulam, Hong Kong
Loey Lung Yi Mak
Recruiting

United States

Gsk Investigational Site
Arcadia, California, United States
Elias Tarakji
Recruiting
Gsk Investigational Site
Covina, California, United States
Masoud Azizad
Recruiting
Gsk Investigational Site
Los Angeles, California, United States
Joseph Lamb
Recruiting
Gsk Investigational Site
San Diego, California, United States
Julie Doan Trang Vu
Recruiting
Gsk Investigational Site
Santa Maria, California, United States
Keval Shah
Recruiting
Gsk Investigational Site
Van Nuys, California, United States
Robert Jenders
Recruiting
Gsk Investigational Site
Boynton Beach, Florida, United States
Aaron Cohen
Recruiting
Gsk Investigational Site
Cape Coral, Florida, United States
Paige Kreegel
Recruiting
Gsk Investigational Site
Doral, Florida, United States
Jorge Diaz
Recruiting
Gsk Investigational Site
Hialeah, Florida, United States
Isaac Bassan
Recruiting
Gsk Investigational Site
Homestead, Florida, United States
Gilberto Seco
Recruiting
Gsk Investigational Site
Inverness, Florida, United States
Paul Hellstern Jr.
Recruiting
Gsk Investigational Site
Jacksonville, Florida, United States
Jeffry Jacqmein
Recruiting
Gsk Investigational Site
Kissimmee, Florida, United States
Luis Alvarado Lopez
Recruiting
Gsk Investigational Site
Lakeland, Florida, United States
James Andersen
Recruiting
Gsk Investigational Site
Maitland, Florida, United States
Eva Maria Heurich
Recruiting
Gsk Investigational Site
Miami, Florida, United States
Franciso Bautista
Recruiting
Gsk Investigational Site
Miami, Florida, United States
Barbara Moscoso
Recruiting
Gsk Investigational Site
Miami, Florida, United States
Lazaro M Garcia
Recruiting
Gsk Investigational Site
Miami, Florida, United States
Jorge Amaya
Recruiting
Gsk Investigational Site
Miami, Florida, United States
Yaneicy Gonzalez Rojas
Recruiting
Gsk Investigational Site
Miami Lakes, Florida, United States
Miguel Aponte
Recruiting
Gsk Investigational Site
Ocala, Florida, United States
Robert Barish
Recruiting
Gsk Investigational Site
Palmetto Bay, Florida, United States
Karen Figueredo Reyes
Recruiting
Gsk Investigational Site
Sarasota, Florida, United States
Guy Neff
Recruiting
Gsk Investigational Site
Topeka, Kansas, United States
Shekhar Challa
Recruiting
Gsk Investigational Site
Marrero, Louisiana, United States
Gary Reiss
Recruiting
Gsk Investigational Site
Springfield, Missouri, United States
Dmitry Shuster
Recruiting
Gsk Investigational Site
St Louis, Missouri, United States
Fred Williams
Recruiting
Gsk Investigational Site
Jersey City, New Jersey, United States
Samar Hameed
Recruiting
Gsk Investigational Site
East Syracuse, New York, United States
Barbara Connor
Recruiting
Gsk Investigational Site
New York, New York, United States
Eli Shalenberg
Recruiting
Gsk Investigational Site
Morehead City, North Carolina, United States
Kathryn Lucas
Recruiting
Gsk Investigational Site
Akron, Ohio, United States
Ganesh Veerappan
Recruiting
Gsk Investigational Site
Springboro, Ohio, United States
Anjali Morey
Recruiting
Gsk Investigational Site
Chattanooga, Tennessee, United States
Chirag Patel
Recruiting
Gsk Investigational Site
Austin, Texas, United States
Michael Patrick Zimmerman
Recruiting
Gsk Investigational Site
Austin, Texas, United States
Nomita Kim
Recruiting
Gsk Investigational Site
Brownsville, Texas, United States
Christopher Romero
Recruiting

13 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Efimosfermin alfaPlacebo

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 12 Dec 2025
Primary completion: 24 Mar 2028
Completion: 24 Mar 2028
Last update posted: 27 Jul 2026
Registered enrollment: 1,250
Registry id: NCT07221188

Cross-registrations

EU-CTR / CTIS (EudraCT)2025-523674-16

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.