Clinical trialNCT07326709RecruitingPhase 3Interventional

A Study to Investigate the Efficacy, Safety and Tolerability of Votoplam in Participants With Huntington's Disease

SponsorNovartis PharmaceuticalsEnrollment770Huntington Disease

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The purpose is to assess safety and tolerability of votoplam and to determine whether votoplam slows disease progression in patients with early symptomatic Huntington's disease (HD) compared to the control arm. HTT227 - current compound code (former code is PTC518 from PTC Therapeutics), HTT227 is Novartis code under Novartis sponsorship.

clinicaltrials.gov ↗

Investigators

No overall officials are registered on this study record. Site-level investigators, where published, appear with their sites below. Why? →

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

60 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Argentina

Novartis Investigative Site
CABA, Buenos Aires, Argentina
Recruiting
Novartis Investigative Site
CABA, Buenos Aires, Argentina
Recruiting

Australia

Novartis Investigative Site
Caulfield South, Victoria, Australia
Recruiting

Belgium

Novartis Investigative Site
Leuven, Vlaams Brabant, Belgium
Recruiting

Canada

North York General Hospital
North York, Ontario, Canada
Ragini Srinivasan, MD
Recruiting
Cusm Montreal Neurological Institute
Montreal, Quebec, Canada
Anne-Louise Lafontaine
Recruiting
Centre de Recherche Du Chum
Montreal, Quebec, Canada
Alby Richard
Recruiting

China

Novartis Investigative Site
Wuhan, Hubei, China
Recruiting
Novartis Investigative Site
Changsha, Hunan, China
Recruiting
West China Hospital of Sichuan Uni
Chengdu, Sichuan, China
Huifang Shang
Recruiting
Novartis Investigative Site
Hangzhou, Zhejiang, China
Recruiting

France

Novartis Investigative Site
Montpellier, France
Recruiting

Israel

Tel Aviv Sourasky Med Ctr Ichilov
Tel Aviv, Israel
Tanya Gurevich
Recruiting

Japan

Novartis Investigative Site
Bunkyo Ku, Tokyo, Japan
Recruiting

South Korea

Novartis Investigative Site
Daejeon, Korea, South Korea
Recruiting
Smg Snu Boramae Medical Center
Dongjak Gu, Seoul, South Korea
Recruiting
Seoul National University Hospital
Seoul, Seoul, South Korea
Recruiting
Inje University Busan Paik Hospital
Busan, South Korea
Recruiting

Spain

Novartis Investigative Site
Seville, Spain
Recruiting

Switzerland

Novartis Investigative Site
Basel, Switzerland
Recruiting
Novartis Investigative Site
Muri bei Bern, Switzerland
Recruiting

Taiwan

Novartis Investigative Site
Changhua, Taiwan
Recruiting
Novartis Investigative Site
Taipei, Taiwan
Recruiting

United Kingdom

Novartis Investigative Site
Exeter, Devon, United Kingdom
Recruiting
Novartis Investigative Site
Aberdeen, Grampian Region, United Kingdom
Recruiting
Novartis Investigative Site
Cambridge, United Kingdom
Recruiting
Novartis Investigative Site
Cardiff, United Kingdom
Recruiting
Novartis Investigative Site
Glasgow, United Kingdom
Recruiting
University College Hospital
London, United Kingdom
Sarah Tabrizi
Recruiting
Novartis Investigative Site
Oxford, United Kingdom
Recruiting
Southampton General Hospital
Southampton, United Kingdom
Christopher Kipps
Recruiting

United States

University of Ca San Diego
La Jolla, California, United States
Jody Corey-Bloom
Recruiting
Uc Davis Health System
Sacramento, California, United States
Alexandra Duffy
Recruiting
Stanford Healthcare
Stanford, California, United States
Hengameh Zahed Kargaran
Recruiting
Cenexcel Rocky Mtn Clin Research
Englewood, Colorado, United States
Meagen Salinas
Recruiting
U Conn Health
Farmington, Connecticut, United States
Shakaib Khan
Recruiting
Georgetown University
Washington D.C., District of Columbia, United States
Karen Anderson
Recruiting
University of South Florida
Tampa, Florida, United States
Theresa Zesiewicz →
Recruiting
Parkinsons-Movement Disorder Ctr
Chicago, Illinois, United States
Danny Bega
Recruiting
Indiana University Health
Indianapolis, Indiana, United States
Christopher James
Recruiting

20 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

PlaceboVotoplam

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 24 Mar 2026
Primary completion: 2 Apr 2030
Completion: 30 Apr 2030
Last update posted: 11 Aug 2026
Registered enrollment: 770
Registry id: NCT07326709

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.