Clinical trialNCT01251406CompletedPhase 2Interventional

Efficacy and Safety of Human Neuregulin-1 to Treat Stable Chronic Heart Failure

SponsorZensun Sci. & Tech. Co., Ltd.Enrollment67Chronic Heart Failure

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The mortality of chronic heart failure patients remains high. Recombinant human Neuregulin-1 (rhNRG-1, also called Neucardin) is a 61 amino acid peptide that acts directly on damaged heart muscle cells to restore their structure and function. This study will investigate the safety and efficacy of rhNRG-1 to treat stable chronic heart failure.

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Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Barry Greenberg, MD
University of California, San Diego
Study ChairKOL profile →
clinicaltrials.gov ↗
Uri Elkayam, MD
LAC+USC Medical Center
Principal Investigator
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A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

13 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

University of California, San Diego
La Jolla, California, United States
Metabolic Clinic and Research Center
Los Angeles, California, United States
Usc Cardiovascular Division
Los Angeles, California, United States
Orange County Research Center
Tustin, California, United States
University of Colorado Denver
Denver, Colorado, United States
Clearwater Cardiovascular & Interventional Consultants, Md, Pa
Clearwater, Florida, United States
University of South Florida
Tampa, Florida, United States
University of Iowa Hospitals and Clinics
Iowa City, Iowa, United States
Medpharmics, Llc.
Kenner, Louisiana, United States
Benchmark Research
Metairie, Louisiana, United States
East Texas Cardiology
Houston, Texas, United States
the Medical Center of Plano
Plano, Texas, United States
Sentara Cardiovascular Research Institute
Norfolk, Virginia, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

PlaceboRhNRG-1 Dose 1RhNRG-1 Dose 2

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 31 Jan 2012
Primary completion: 31 Dec 2012
Completion: 31 Mar 2014
Last update posted: 10 Feb 2025
Registered enrollment: 67
Registry id: NCT01251406

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.