Clinical trialNCT03509961RecruitingPhase 2Interventional

The EndRAD Trial: Eliminating Total Body Irradiation (TBI) for NGS-MRD Negative Children, Adolescents, and Young Adults With B-ALL

SponsorPediatric Transplantation & Cellular Therapy ConsortiumEnrollment95B-cell Acute Lymphoblastic Leukemia

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This study will evaluate the use of non- TBI (total body irradiation) conditioning for B-ALL patients with low risk of relapse as defined by absence of NGS-MRD (next generation sequencing minimal residual disease) before receiving a hematopoietic cell transplant (HCT). Patients diagnosed with B-ALL who are candidates for HCT will be screened by NGS-MRD on a test of bone marrow done before the HCT. Subjects who are pre-HCT NGS-MRD negative will be eligible to receive a non-TBI conditioning regimen as part of the treatment cohort of the study. Subjects who are pre-HCT NGS-MRD positive will be treated as per treating center standard and will be followed in an observational cohort (HCT center standard of care).

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Abdel-Azim Hisham, MD
Loma Linda University
Principal Investigator
clinicaltrials.gov ↗
Troy Quigg, DO, MS
Helen DeVos Children's Hospital
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

24 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Children'S of Alabama/university of Alabama in Birmingham(uab)
Birmingham, Alabama, United States
Joseph Chewning, MD
Recruiting
Phoenix Children'S Hospital
Phoenix, Arizona, United States
Dana Salzberg, MD
Recruiting
City of Hope
Duarte, California, United States
Anna Pawlowska, MD
Recruiting
Children'S Hospital Los Angeles
Los Angeles, California, United States
Hisham Abdel-Azim, MD
Recruiting
Ucla Mattel Children'S Hospital
Los Angeles, California, United States
Ted Moore, MD
Recruiting
Ucsf Benioff Children'S Hospital Oakland
Oakland, California, United States
nahal Lalefar, MD
Recruiting
Ucsf
San Francisco, California, United States
Christine Higham, MD
Recruiting
Children'S Hospital Colorado
Aurora, Colorado, United States
Amy Keating, MD
Recruiting
Yale University School of Medicine
New Haven, Connecticut, United States
Niketa Shah, MD
Recruiting
Alfred I. Dupont Hospital for Children - Nemours Deleware
Wilmington, Delaware, United States
Emi Caywood, MD
Recruiting
University of Florida
Gainesville, Florida, United States
Biljana Horn, MD
Recruiting
Nicklaus Children'S Hospital
Miami, Florida, United States
Jorge Galvez, MD
Recruiting
Johns Hopkins All Children'S Hospital
St. Petersburg, Florida, United States
Benjamin Shrine, MD
Recruiting
Children'S Healthcare of Atlanta
Atlanta, Georgia, United States
Muna Qayed, MD
Recruiting
Riley Hospital for Children - Indiana University
Indianapolis, Indiana, United States
Jodi Skiles, MD
Recruiting
Dana Faber Cancer Institute/ Boston Children'S Hospital
Boston, Massachusetts, United States
Steven Margossian, MD
Recruiting
Floating Hospital for Children at Tufts Medical Center
Boston, Massachusetts, United States
Jason Law, MD
Recruiting
Helen Devos Children'S Hospital at Spectrum Health
Grand Rapids, Michigan, United States
Ulrich Duffner, MD
Recruiting
Children'S Mercy Hospital
Kansas City, Missouri, United States
Ibrahim Ahmed, MD
Recruiting
Hackensack University Medical Center
Hackensack, New Jersey, United States
Jennifer Krajewski, MD
Recruiting
Roswell Park Cancer Institute
Buffalo, New York, United States
Barbara Bambach, MD
Recruiting
Atrium Health - Levine Cancer Center
Charlotte, North Carolina, United States
Jeffrey Huo, MD
Recruiting
the University of Texas M. D. Anderson Cancer Center
Houston, Texas, United States
Kris Mahadeo, MD
Recruiting
Methodist Healthcare System
San Antonio, Texas, United States
Troy Quigg, DO
Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Myeloablative allogeneic HCT with a non-TBI conditioning regimen

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 29 Aug 2018
Primary completion: 1 Jul 2025
Completion: 1 Jul 2026
Last update posted: 4 May 2025
Registered enrollment: 95
Registry id: NCT03509961

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.