Clinical trialNCT04104776RecruitingPhase 1/PHASE2Interventional

A Study of Tulmimetostat DZR123 (CPI-0209) in Patients With Advanced Solid Tumors and Lymphomas

SponsorNovartis PharmaceuticalsEnrollment300Advanced Solid TumorDiffuse Large B Cell LymphomaEndometrial CancerLymphoma, T-CellMesothelioma, MalignantMetastatic Castration-resistant Prostate Cancer+2 more conditions

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The purpose of this open-label, first-in-human (FIH) trial is to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary antitumor activity of DZR123 (Tulmimetostat, CPI-0209), both as monotherapy and in combination with enzalutamide, in patients with advanced solid tumors and lymphomas.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Novartis Pharmaceuticals
Novartis Pharmaceuticals
Study Director
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

80 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

France

Chu Bordeaux Hopital Saint Andre
Bordeaux, France
Withdrawn
Clcc Institut Bergonie
Bordeaux, France
Antoine Italiano
Recruiting
Centre Oscar Lambret
Lille, France
Cyril Abdeddaim
Recruiting
Centre Leon Berard
Lyon, France
Medhi Brahmi
Recruiting
Chu Nantes Hopital Hotel Dieu
Nantes, France
Caroline Viala
Recruiting
Chu Nantes Hopital Nord Laennec
Saint-Herblain, France
Caroline Viala
Recruiting
Hopital Hautepierre
Strasbourg, France
Lauriane Eberst
Recruiting
Gustave Roussy
Villejuif, France
Vincent Ribrag
Recruiting

Italy

Irccs University Hospital of Bologna
Bologna, Italy
Completed
European Institute of Oncology (ieo), Irccs
Milan, Italy
Completed
European Institute of Oncology (ieo), Irccs
Milan, Italy
Franco Nole
Recruiting
Humanitas San Pio X
Milan, Italy
Domenica Lorusso
Recruiting
National Cancer Institute, Irccs
Milan, Italy
Mara Mantiero
Recruiting
National Cancer Institute, Irccs
Milan, Italy
Withdrawn
University Polyclinic Foundation "agostino Gemelli" - Irccs
Roma, Italy
Vanda Salutari
Recruiting
Gruppo Humanitas - Humanitas Research Hospital - Cancer Center
Rozzano, Italy
Carmelo Carlo-Stella
Recruiting

Poland

University Teaching Centre, Early Clinical Trials Unit
Gdansk, Poland
Rafal Dziadziuszko
Recruiting
Pratia Mcm Krakow
Krakow, Poland
Withdrawn
Polish Mother'S Memorial Hospital-Research Institute
Lodz, Poland
Withdrawn
Pratia - Poznan
Poznan, Poland
Completed
University Teaching Hospital in Poznan, Department of Gynecologic Oncology
Poznan, Poland
Radoslaw Madry
Recruiting
Maria Sklodowska-Curie - National Research Institute of Oncology
Warsaw, Poland
Completed

South Korea

Keimyung University - Dongsan Medical Center
Daegu, South Korea
Withdrawn
National Cancer Center
Goyang-si, South Korea
Completed
Gachon University Gil Medical Center
Incheon, South Korea
Kwang-Beom Lee
Recruiting
Asan Medical Center
Seoul, South Korea
Shin Wha Lee
Recruiting
Gangnam Severance Hospital
Seoul, South Korea
Jae-Hoon Kim
Recruiting
Seoul National University Hospital
Seoul, South Korea
Jae Weon Kim
Recruiting
Severance Hospital, Yonsei University Health System
Seoul, South Korea
Jung-Yun Lee
Recruiting
the Catholic University of Korea, Seoul St. Mary'S Hospital
Seoul, South Korea
Withdrawn

Spain

Hospital Clinic of Barcelona
Barcelona, Spain
Begona Mellado Gonzalez
Recruiting
University Hospital Vall D'Hebron
Barcelona, Spain
Ana Oaknin
Recruiting
University Hospital of Girona Dr. Josep Trueta
Girona, Spain
Maria Pilar Barretina Ginesta
Recruiting
Catalan Institute of Oncology, Hospital Duran I Reynals
L'Hospitalet de Llobregat, Spain
Withdrawn
University Clinic of Navarra - Madrid
Madrid, Spain
Antonio Gonzalez Martin
Recruiting
University Hospital 12 de Octubre
Madrid, Spain
Completed
University Hospital Clinical San Carlos, Department of Medical Oncology
Madrid, Spain
Jorge Bartolome Arcilla
Recruiting
University Hospital Foundation Jimenez Diaz
Madrid, Spain
Bernard Gaston Doger De Speville
Recruiting
University Hospital Quiron Madrid
Madrid, Spain
Jesus Fuentes Antras
Recruiting
University Hospital Ramon Y Cajal
Madrid, Spain
Teresa Alonso Gordoa
Recruiting

40 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Enzalutamide →Tulmimetostat

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 18 Sept 2019
Primary completion: 27 Feb 2030
Completion: 27 Feb 2030
Last update posted: 19 Aug 2026
Registered enrollment: 300
Registry id: NCT04104776

Cross-registrations

EU-CTR / CTIS (EudraCT)2023-508002-20-00

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.