Clinical trialNCT04372524UnknownObservational

Biomarker Verification in Pediatric Chronic GvHD: ABLE 2.0 / PTCTC GVH 1901 Study

SponsorUniversity of British ColumbiaEnrollment350Allogeneic Hematopoietic Stem Cell TransplantationBlood CancerChronic Graft-versus-Host-DiseaseLeukemiaNon-Malignant Hematologic and Lymphocytic Disorder

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This study will validate a previously developed pediatric prognostic biomarker algorithm aimed at improving prediction of risk for the later development of chronic graft-versus-host disease (cGvHD) in children and young adults undergoing allogeneic hematopoietic stem cell transplant. By developing an early risk stratification of patients into low-, intermediate-, and high-risk for future cGvHD development (based upon their biomarker profile, before the onset of cGvHD), pre-emptive therapies aimed at preventing the onset of cGvHD can be developed based upon an individual's biological risk profile. This study will also continue research into diagnostic biomarkers of cGvHD, and begin work into biomarker models that predict clinical response to cGvHD therapies.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Andrew C Harris, MD
Memorial Sloan Kettering Cancer Center / Pediatric Stem Cell Transplantation and Cellular Therapies
Principal Investigator
clinicaltrials.gov ↗
Kirk R Schultz, MD
University of British Columbia / BC Children's Hospital Research Institute
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

16 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Canada

Alberta Children'S Hospital
Calgary, Alberta, Canada
Victor Lewis, MD
Recruiting
Bc Children'S Hospital
Vancouver, British Columbia, Canada
Amanda Li, MD, MScJacob Rozmus, MD, PhDKirk R. Schultz, MD
Recruiting
Cancercare Manitoba
Winnipeg, Manitoba, Canada
Active, not recruiting
Chu Sainte-Justine
Montreal, Quebec, Canada
Henrique Bittencourt, MD, PhD
Recruiting
Mcgill University Health Centre
Montreal, Quebec, Canada
David Mitchell, MD
Recruiting

United States

University of California San Francisco
San Francisco, California, United States
Alexis Melton, MD
Recruiting
Children'S Hospital Colorado
Denver, Colorado, United States
Amy Keating, MD
Recruiting
Emory University School of Medicine
Atlanta, Georgia, United States
Muna Qayed, MD, MsCR
Not, yet, recruiting
Washington University School of Medicine
St Louis, Missouri, United States
Shalini Shenoy, MO, MD
Not, yet, recruiting
Roswell Park Comprehensive Care Center
Buffalo, New York, United States
Nataliya Prokopenko Buxbaum, MD
Recruiting
Memorial Sloan Kettering Cancer Center
New York, New York, United States
Andrew C Harris, MD
Recruiting
University of North Carolina
Chapel Hill, North Carolina, United States
Kimberly A Kasow, DO
Not, yet, recruiting
Atrium Health Levine Cancer Institute
Charlotte, North Carolina, United States
Michael W Kent, MD
Recruiting
Nationwide Children'S Hospital
Columbus, Ohio, United States
Rajinder Bajwa, MD
Recruiting
Oregon Health & Science University Knight Cancer Institute
Portland, Oregon, United States
Eneida R Nemecek, MD, MS, MBA
Recruiting
Vanderbilt University Medical Center
Nashville, Tennessee, United States
Carrie L Kitko, MD
Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study. It may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 15 Nov 2020
Primary completion: 31 Jan 2024
Completion: 31 Jan 2025
Last update posted: 5 Dec 2023
Registered enrollment: 350
Registry id: NCT04372524

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.