Clinical trialNCT04510597RecruitingPhase 3Interventional

Comparing the Outcome of Immunotherapy-Based Drug Combination Therapy With or Without Surgery to Remove the Kidney in Metastatic Kidney Cancer, the PROBE Trial

SponsorSWOG Cancer Research NetworkEnrollment364Metastatic Clear Cell Renal Cell CarcinomaMetastatic Renal Cell CarcinomaStage IV Renal Cell Cancer AJCC v8

View the registry record on ClinicalTrials.gov

Summary

The registered summary isn't in our current data snapshot. Read it on the ClinicalTrials.gov record ↗. Why? →

Investigators

No overall officials are registered on this study record. Site-level investigators, where published, appear with their sites below. Why? →

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

387 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

University of Alabama at Birmingham Cancer Center
Birmingham, Alabama, United States
Arnab Basu
Recruiting
Banner Md Anderson Cancer Center
Gilbert, Arizona, United States
Chinedu Mmeje
Recruiting
Kingman Regional Medical Center
Kingman, Arizona, United States
John A. Ellerton
Recruiting
Banner University Medical Center - Tucson
Tucson, Arizona, United States
Benjamin R. Lee
Recruiting
University of Arizona Cancer Center-North Campus
Tucson, Arizona, United States
Benjamin R. Lee
Recruiting
Mercy Hospital Fort Smith
Fort Smith, Arkansas, United States
Jay W. Carlson
Recruiting
Pcr Oncology
Arroyo Grande, California, United States
John A. Ellerton
Recruiting
Sutter Auburn Faith Hospital
Auburn, California, United States
Ari D. Baron
Recruiting
Sutter Cancer Centers Radiation Oncology Services-Auburn
Auburn, California, United States
Ari D. Baron
Recruiting
Alta Bates Summit Medical Center-Herrick Campus
Berkeley, California, United States
Ari D. Baron
Recruiting
Keck Medicine of Usc Buena Park
Buena Park, California, United States
Varsha Tulpule
Recruiting
Sutter Cancer Centers Radiation Oncology Services-Cameron Park
Cameron Park, California, United States
Ari D. Baron
Recruiting
Eden Hospital Medical Center
Castro Valley, California, United States
Ari D. Baron
Recruiting
Sutter Davis Hospital
Davis, California, United States
Ari D. Baron
Recruiting
City of Hope Comprehensive Cancer Center
Duarte, California, United States
Abhishek Tripathi
Recruiting
Palo Alto Medical Foundation-Fremont
Fremont, California, United States
Ari D. Baron
Recruiting
Keck Medicine of Usc Huntington Beach
Huntington Beach, California, United States
Varsha Tulpule
Recruiting
Cedars Sinai Medical Center
Los Angeles, California, United States
Hyung L. Kim
Recruiting
Keck Medicine of Usc Koreatown
Los Angeles, California, United States
Varsha Tulpule
Recruiting
Los Angeles County-Usc Medical Center
Los Angeles, California, United States
Varsha Tulpule
Recruiting
Ucla / Jonsson Comprehensive Cancer Center
Los Angeles, California, United States
Brian Shuch
Recruiting
Usc / Norris Comprehensive Cancer Center
Los Angeles, California, United States
Varsha Tulpule
Recruiting
Memorial Medical Center
Modesto, California, United States
Ari D. Baron
Recruiting
Palo Alto Medical Foundation-Camino Division
Mountain View, California, United States
Ari D. Baron
Recruiting
Palo Alto Medical Foundation-Gynecologic Oncology
Mountain View, California, United States
Ari D. Baron
Recruiting
Usc Norris Oncology/hematology-Newport Beach
Newport Beach, California, United States
Varsha Tulpule
Recruiting
Sutter Cancer Research Consortium
Novato, California, United States
Ari D. Baron
Recruiting
Palo Alto Medical Foundation Health Care
Palo Alto, California, United States
Ari D. Baron
Recruiting
Keck Medical Center of Usc Pasadena
Pasadena, California, United States
Varsha Tulpule
Recruiting
Sutter Cancer Centers Radiation Oncology Services-Roseville
Roseville, California, United States
Ari D. Baron
Recruiting
Sutter Roseville Medical Center
Roseville, California, United States
Ari D. Baron
Recruiting
Sutter Medical Center Sacramento
Sacramento, California, United States
Ari D. Baron
Recruiting
University of California Davis Comprehensive Cancer Center
Sacramento, California, United States
Shuchi Gulati
Recruiting
California Pacific Medical Center-Pacific Campus
San Francisco, California, United States
Ari D. Baron
Recruiting
Mills Health Center
San Mateo, California, United States
Ari D. Baron
Recruiting
Palo Alto Medical Foundation-Santa Cruz
Santa Cruz, California, United States
Ari D. Baron
Recruiting
Sutter Pacific Medical Foundation
Santa Rosa, California, United States
Ari D. Baron
Recruiting
City of Hope South Pasadena
South Pasadena, California, United States
Abhishek Tripathi
Recruiting
Palo Alto Medical Foundation-Sunnyvale
Sunnyvale, California, United States
Ari D. Baron
Recruiting
Cedars-Sinai Cancer - Tarzana
Tarzana, California, United States
Hyung L. Kim
Recruiting

347 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study — it may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 8 Mar 2021
Primary completion: 31 Jul 2033
Completion: 31 Jul 2033
Last update posted: 9 Sept 2025
Registered enrollment: 364
Registry id: NCT04510597

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 12 Jul 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.