Clinical trialNCT05836987RecruitingPhase 3Interventional

The Rhythm Evaluation for AntiCoagulaTion With Continuous Monitoring of Atrial Fibrillation

SponsorJohns Hopkins UniversityEnrollment5,350Atrial Fibrillation

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

REACT-AF is a multicenter prospective, randomized, open-label, blinded endpoint (PROBE design), controlled trial comparing the current Standard Of Care (SOC) of continuous Direct Oral Anticoagulation (DOAC) use versus time-delimited (1 month) DOAC guided by an AF-sensing Smart Watch (AFSW) in participants with a history of paroxysmal or persistent Atrial Fibrillation (AF) and low-to-moderate stroke risk.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Dan Hanley
Johns Hopkins University
Principal Investigator
clinicaltrials.gov ↗
Rod Passman
Northwestern University
Principal InvestigatorKOL profile →
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

93 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Banner University
Phoenix, Arizona, United States
Roderick Tung, MD
Recruiting
University of California Los Angeles (ucla Health)
Los Angeles, California, United States
David Cho, MD
Recruiting
University of Southern California - Keck School of Medicine
Los Angeles, California, United States
Junaid Zaman, MD
Recruiting
Uc Davis Health
Sacramento, California, United States
Uma Srivatsa
Recruiting
Scripps Health
San Diego, California, United States
Evan Muse
Recruiting
Kaiser Permanente
San Francisco, California, United States
Robert Hayward, MD
Not, yet, recruiting
Stanford University
Stanford, California, United States
Alexander Perino
Recruiting
University of Colorado
Aurora, Colorado, United States
Amar Trivedi
Recruiting
South Denver Cardiology Associates, P.C.
Littleton, Colorado, United States
Srikanth Sundaram
Recruiting
Medical Faculty Associates George Washington University
Washington D.C., District of Columbia, United States
Withdrawn
St. Elizabeth'S Medical Center
Washington D.C., District of Columbia, United States
John Wylie
Recruiting
Baycare Health Systems
Clearwater, Florida, United States
Shalin Shah
Recruiting
University of Florida
Gainesville, Florida, United States
Mohammed Ruzieh, MD
Recruiting
Mayo Clinic
Jacksonville, Florida, United States
Andrew Tseng, MD
Recruiting
University of Miami - Leonard S. Miller Som
Miami, Florida, United States
Alex Velasquez, MD
Recruiting
Sarasota Memorial Health Care System
Sarasota, Florida, United States
Dilip Mathew, MD
Recruiting
Cleveland Clinic Florida
Stuart, Florida, United States
Withdrawn
Baycare Health Systems Clearwater
Winter Haven, Florida, United States
Rodrigo Bolanos, MD
Recruiting
Emory University
Atlanta, Georgia, United States
Michael Lloyd
Recruiting
Georgia Arrhythmia Consultants and Research Institute
Warner Robins, Georgia, United States
Feliz Sogade, MD
Recruiting
Loyola University Chicago
Chicago, Illinois, United States
Peter Santucci, MD
Recruiting
Northwestern University
Chicago, Illinois, United States
Bradley Knight
Recruiting
Rush University Medical Center
Chicago, Illinois, United States
Annabelle Volgman, MD
Recruiting
University of Chicago
Chicago, Illinois, United States
Cevher Ozcan, MD
Recruiting
University of Illinois Chicago
Chicago, Illinois, United States
David Sanders
Recruiting
Alexian Brothers Health System
Elk Grove Village, Illinois, United States
Taral Patel, MD
Recruiting
Northshore University Healthsystem
Evanston, Illinois, United States
Jeremiah Wasserlauf, MD
Recruiting
Midwest Cardiovascular Institute
Naperville, Illinois, United States
Moeen Saleem
Recruiting
Ascension St. Vincent
Indianapolis, Indiana, United States
Eric Prystowsky
Recruiting
University of Iowa Hospitals and Clinics
Iowa City, Iowa, United States
Peter Farjo
Recruiting
Maine Medical Partners Mainehealth Cardiology
Scarborough, Maine, United States
Jordan Leyton-Mange, MD
Recruiting
Johns Hopkins Univeristy
Baltimore, Maryland, United States
Hugh Calkins →
Recruiting
Bmc - Brighton
Boston, Massachusetts, United States
Alena Goldman, MD
Recruiting
Beth Israel Deaconess Medical Center
Boston, Massachusetts, United States
Peter Zimetbaum, MD
Recruiting
Boston Medical Center
Boston, Massachusetts, United States
Robert Helm
Recruiting
Brigham and Women'S Hospital
Boston, Massachusetts, United States
Paul Zei, MD
Recruiting
Mass General Hospital
Boston, Massachusetts, United States
Eugene Chung
Not, yet, recruiting
Tufts Medical Center
Boston, Massachusetts, United States
Christopher Madias, MD
Recruiting
Lahey Hospital & Medical Center
Burlington, Massachusetts, United States
Matthew Reynolds →
Recruiting
Umass Chan Medical School
Worcester, Massachusetts, United States
Active, not recruiting

53 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Continuous DOAC therapy

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 13 Jul 2023
Primary completion: 31 Jul 2029
Completion: 31 Jul 2029
Last update posted: 19 Aug 2026
Registered enrollment: 5,350
Registry id: NCT05836987

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.