Clinical trialNCT05650658RecruitingInterventional

Left vs Left Randomized Clinical Trial

SponsorBaylor College of MedicineEnrollment2,136AV BlockHeart FailureHeart Failure With Reduced Ejection FractionIntraventricular Conduction DelayLBBBPacing-Induced Cardiomyopathy+1 more conditions

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The investigators aim to prospectively test the comparative effectiveness of His or Left bundle branch pacing in relation to patient centered outcomes (quality of life, physical activity, heart failure hospitalization, mortality) and comparative safety in relation to device-related complications and re-interventions (e.g., lead dislodgement, infection) relative to standard of care biventricular pacing in patients with heart failure due to left ventricular systolic dysfunction (LVEF≤50%) and with either a wide QRS (≥130 ms) or with/anticipated \>40% pacing who are already receiving current standard heart failure pharmacological therapy.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Kenneth A Ellenbogen, MD
Virginia Commonwealth University
Principal InvestigatorKOL profile →
clinicaltrials.gov ↗
Mihail G Chelu, MD, PhD
Baylor College of Medicine
Principal InvestigatorKOL profile →
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

71 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Canada

Mazankowski Alberta Heart Institute/university of Alberta
Edmonton, Alberta, Canada
Evan Martow, MD
Not, yet, recruiting
University of British Columbia
Vancouver, British Columbia, Canada
Jason Andrade, MD
Recruiting
Victoria Cardiac Arrhythmia Trials (vcat) Inc.
Victoria, British Columbia, Canada
Laurence Sterns, MD
Recruiting
Nova Scotia Health Authority
Halifax, Nova Scotia, Canada
Ratika Parkash, MD
Recruiting
Hamilton Health Sciences (hhs)
Hamilton, Ontario, Canada
Jorge Wong, MD
Recruiting
Newmarket Electrophysiology Research Group Inc. (nerg)
Newmarket, Ontario, Canada
Mouhannad Sadek, MD
Recruiting
University of Ottawa Heart Institute
Ottawa, Ontario, Canada
Calum Redpath, MD
Recruiting
Sunnybrook Research Institute
Toronto, Ontario, Canada
Christopher Cheung, MD
Recruiting
Montreal Heart Institute
Montreal, Quebec, Canada
Alexandre Raymond-Paquin, MD
Recruiting
Ciusss de L'Estrie - Chus
Saint-Jean-sur-Richelieu, Quebec, Canada
Félix Ayala-Paredes, MD
Not, yet, recruiting
University of Calgary
Calgary, Canada
Derek Exner
Recruiting
Waterloo Wellington Cardiovascular Research Institute (wwcri) - St. Mary'S General Hospital
Kitchener, Canada
Claus Rinne
Recruiting
Research Institute of the Mcgill University Health Centre (ri-Muhc) - Muhc, Montreal General Hospital
Montreal, Canada
Jacqueline Joza
Recruiting
Université Laval
Québec, Canada
Francois Philippon, MD
Recruiting

United States

Mercy Gilbert & Chandler Regional Medical Centers, Gilbert Az
Gilbert, Arizona, United States
Jaskanwal Bisla, MD
Recruiting
University of Arizona College of Medicine- Phoenix
Tucson, Arizona, United States
Michael Zawaneh, MD
Recruiting
University of Arkansas for Medical Sciences (uams)
Little Rock, Arkansas, United States
Subodh Devabhaktuni, MD
Recruiting
University of California San Diego
La Jolla, California, United States
Farshad Raissi, MD
Recruiting
University of Colorado (anschutz Medical Campus)
Denver, Colorado, United States
Matthew Zipse, MD
Recruiting
South Denver Cardiology Associates
Littleton, Colorado, United States
Srikanth Sundaram, MD
Recruiting
Hartford Hospital
Hartford, Connecticut, United States
Eric Crespo, MD
Recruiting
Yale University
New Haven, Connecticut, United States
Mark Blitzer, MD
Recruiting
Heart Rhythm Solutions
Davie, Florida, United States
Awais K Humayun, MD
Recruiting
University of Florida Jacksonville
Jacksonville, Florida, United States
Aditya Saini, MD
Not, yet, recruiting
Mount Sinai Medical Center of Florida, Inc.
Miami Beach, Florida, United States
Jose Sleiman, MD
Not, yet, recruiting
Cleveland Clinic Florida
Palm Beach Gardens, Florida, United States
Ricardo Hernandez, MD
Recruiting
Florida Heart and Vascular, Llc Dba Florida Heart Rhythm Specialist, Pllc
South Pasadena, Florida, United States
David Kenigsberg, MD
Not, yet, recruiting
University of South Florida
Tampa, Florida, United States
Bengt Herweg, MD
Recruiting
Rush University
Chicago, Illinois, United States
Timothy Larsen, DO
Recruiting
University of Chicago
Chicago, Illinois, United States
Gaurav Upadhyay, MD
Recruiting
Northwestern University
Evanston, Illinois, United States
Nishant Verma, MD
Recruiting
Cis Clinical Research Corporation
Naperville, Illinois, United States
Enrolling, by, invitation
Trustees of Indiana University
Indianapolis, Indiana, United States
Antonio Navarrete, MD
Recruiting
Baptist Health Louisville
Louisville, Kentucky, United States
John Mandrola, MD
Recruiting
Beth Israel Deaconess Medical Center
Boston, Massachusetts, United States
Andrew Locke, MD
Recruiting
Massachusetts General Hospital
Boston, Massachusetts, United States
Shaan Khurshid, MD
Recruiting
Mayo Clinic
Rochester, Minnesota, United States
Yong-Mei Cha, MD
Recruiting
Hmh Hospitals Corporation
Hackensack, New Jersey, United States
Taya Glotzer, MD
Recruiting
Virtua Health
Marlton, New Jersey, United States
Aatish Garg, MD
Recruiting
Newark Beth Israel Medical Center
Newark, New Jersey, United States
David Man, MD
Recruiting

31 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study. It may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 13 Sept 2023
Primary completion: 30 Jun 2029
Completion: 30 Jun 2029
Last update posted: 2 Oct 2025
Registered enrollment: 2,136
Registry id: NCT05650658

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.