Clinical trialNCT06475989RecruitingPhase 3Interventional

Study of Targeted Therapy vs. Chemotherapy in Patients With Thyroid Cancer

SponsorECOG-ACRIN Cancer Research GroupEnrollment264Refractory Differentiated Thyroid Gland Carcinoma

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This phase III trial compares the effect of cabozantinib versus combination dabrafenib and trametinib for the treatment of patients with differentiated thyroid cancer that does not respond to treatment (refractory) and which expresses a BRAF V600E mutation. Cabozantinib is in a class of medications called receptor tyrosine kinase inhibitors. It binds to and blocks the action of several enzymes which are often over-expressed in a variety of tumor cell types. This may help stop or slow the growth of tumor cells and blood vessels the tumor needs to survive. Dabrafenib is an enzyme inhibitor that binds to and inhibits the activity of a protein called B-raf, which may inhibit the proliferation of tumor cells which contain a mutated BRAF gene. Trametinib is also an enzyme inhibitor. It binds to and inhibits the activity of proteins called MEK 1 and 2, which play a key role in activating pathways that regulate cell growth. This may inhibit the growth of tumor cells mediated by these pathways. The usual approach for patients with thyroid cancer is targeted therapy with dabrafenib and trametinib. This trial may help researchers decide which treatment option (cabozantinib alone or dabrafenib in combination with trametinib) is safer and/or more effective in treating patients with refractory BRAF V600E-mutated differentiated thyroid cancer.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Lova Sun
ECOG-ACRIN Cancer Research Group
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

303 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Alaska Breast Care and Surgery Llc
Anchorage, Alaska, United States
Alison K. Conlin
Recruiting
Alaska Oncology and Hematology Llc
Anchorage, Alaska, United States
Alison K. Conlin
Recruiting
Alaska Women'S Cancer Care
Anchorage, Alaska, United States
Alison K. Conlin
Recruiting
Anchorage Associates in Radiation Medicine
Anchorage, Alaska, United States
Alison K. Conlin
Recruiting
Anchorage Radiation Therapy Center
Anchorage, Alaska, United States
Suspended
Katmai Oncology Group
Anchorage, Alaska, United States
Alison K. Conlin
Recruiting
Providence Alaska Medical Center
Anchorage, Alaska, United States
Alison K. Conlin
Recruiting
Fairbanks Memorial Hospital
Fairbanks, Alaska, United States
John M. Schallenkamp
Recruiting
Mercy Hospital Fort Smith
Fort Smith, Arkansas, United States
Jay W. Carlson
Recruiting
Carti Cancer Center
Little Rock, Arkansas, United States
Jay W. Carlson
Recruiting
Providence Saint Joseph Medical Center/disney Family Cancer Center
Burbank, California, United States
Alison K. Conlin
Recruiting
Uci Health - Chao Family Comprehensive Cancer Center and Ambulatory Care
Irvine, California, United States
Shirin Attarian
Recruiting
Providence Queen of the Valley
Napa, California, United States
Alison K. Conlin
Recruiting
Uc Irvine Health/chao Family Comprehensive Cancer Center
Orange, California, United States
Shirin Attarian
Recruiting
Stanford Cancer Institute Palo Alto
Palo Alto, California, United States
Saad A. Khan
Recruiting
Providence Medical Foundation - Santa Rosa
Santa Rosa, California, United States
Alison K. Conlin
Recruiting
Providence Santa Rosa Memorial Hospital
Santa Rosa, California, United States
Alison K. Conlin
Recruiting
Uchealth University of Colorado Hospital
Aurora, Colorado, United States
Daniel W. Bowles
Recruiting
Uchealth Highlands Ranch Hospital
Highlands Ranch, Colorado, United States
Daniel W. Bowles
Recruiting
Smilow Cancer Hospital-Derby Care Center
Derby, Connecticut, United States
Aarti Bhatia
Recruiting
Smilow Cancer Hospital Care Center-Fairfield
Fairfield, Connecticut, United States
Aarti Bhatia
Recruiting
Smilow Cancer Hospital Care Center at Glastonbury
Glastonbury, Connecticut, United States
Aarti Bhatia
Recruiting
Smilow Cancer Hospital Care Center at Greenwich
Greenwich, Connecticut, United States
Aarti Bhatia
Recruiting
Smilow Cancer Hospital Care Center - Guilford
Guilford, Connecticut, United States
Aarti Bhatia
Recruiting
Smilow Cancer Hospital Care Center at Saint Francis
Hartford, Connecticut, United States
Aarti Bhatia
Recruiting
Smilow Cancer Center/yale-New Haven Hospital
New Haven, Connecticut, United States
Aarti Bhatia
Recruiting
Yale University
New Haven, Connecticut, United States
Aarti Bhatia
Recruiting
Yale-New Haven Hospital North Haven Medical Center
North Haven, Connecticut, United States
Aarti Bhatia
Recruiting
Smilow Cancer Hospital Care Center at Long Ridge
Stamford, Connecticut, United States
Aarti Bhatia
Recruiting
Smilow Cancer Hospital-Torrington Care Center
Torrington, Connecticut, United States
Aarti Bhatia
Recruiting
Smilow Cancer Hospital Care Center-Trumbull
Trumbull, Connecticut, United States
Aarti Bhatia
Recruiting
Smilow Cancer Hospital-Waterbury Care Center
Waterbury, Connecticut, United States
Aarti Bhatia
Recruiting
Smilow Cancer Hospital Care Center - Waterford
Waterford, Connecticut, United States
Aarti Bhatia
Recruiting
Holy Cross Hospital
Fort Lauderdale, Florida, United States
Tareq Al baghdadi
Recruiting
Mayo Clinic in Florida
Jacksonville, Florida, United States
Active, not recruiting
Emory University Hospital Midtown
Atlanta, Georgia, United States
Dong M. Shin
Recruiting
Saint Alphonsus Cancer Care Center-Boise
Boise, Idaho, United States
Tareq Al baghdadi
Recruiting
Saint Luke'S Cancer Institute - Boise
Boise, Idaho, United States
Alison K. Conlin
Recruiting
Saint Alphonsus Cancer Care Center-Caldwell
Caldwell, Idaho, United States
Tareq Al baghdadi
Recruiting
Kootenai Health - Coeur D'Alene
Coeur d'Alene, Idaho, United States
John M. Schallenkamp
Recruiting

263 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

CabozantinibDabrafenibTrametinib

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 22 Aug 2024
Primary completion: 30 Sept 2030
Completion: 30 Sept 2030
Last update posted: 6 Aug 2026
Registered enrollment: 264
Registry id: NCT06475989

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.