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Clinical trialNCT06959511RecruitingPhase 2Interventional

Zanzalintinib for the Treatment of Advanced Thyroid Cancer Before Surgery

SponsorM.D. Anderson Cancer CenterEnrollment45Neoadjuvant TreatmentThyroid Cancer
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

To look at the effectiveness of zanzalintinib, followed by surgery, in treating advanced thyroid cancer. The safety of this treatment will also be studied.

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

4 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States
  • University of Michigan

    Ann Arbor, Michigan, United States

    Francis Worden, MD
    Recruiting
  • Cleveland Clinic Taussig Cancer Institute

    Cleveland, Ohio, United States

    Jessica Geiger, MD
    Recruiting
  • Md Anderson Cancer Center

    Houston, Texas, United States

    Mark Zafereo, MD
    Recruiting
  • University of Virginia

    Charlottesville, Virginia, United States

    Varinder Kaur, MD
    Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Zanzalintinib
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
22 Jul 2025
Primary completion
1 Mar 2028
Completion
1 Oct 2030
Last update posted
28 Jul 2026
Registered enrollment
45
Registry id
NCT06959511

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.