Clinical trialNCT06498635RecruitingPhase 3Interventional

Immunotherapy After Surgery for People Who Have No Remaining Cancer Cells After Standard Treatment for Early-Stage Non-Small Cell Lung Cancer, INSIGHT Trial

SponsorNational Cancer Institute (NCI)Enrollment306Lung Non-Small Cell CarcinomaStage II Lung Cancer AJCC v8Stage IIIA Lung Cancer AJCC v8Stage IIIB Lung Cancer AJCC v8

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This phase III trial compares durvalumab to the usual approach (patient observation) after surgery for the treatment of patients with early-stage non-small cell lung cancer. Immunotherapy with monoclonal antibodies, such as durvalumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. The usual approach for patients who are not in a study is to closely watch a patient's condition after surgery and to have regular visits with their doctor to watch for signs of the cancer coming back. Usually, patients do not receive further treatment unless the cancer returns. This study will help determine whether this different approach with durvalumab is better, the same, or worse than the usual approach of observation. Giving durvalumab may help patients live longer and prevent early-stage non-small cell lung cancer from coming back as compared to the usual approach.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Jeremy P Cetnar
SWOG Cancer Research Network
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

278 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Nea Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro
Jonesboro, Arkansas, United States
Osarenren Ogbeide
Recruiting
Tower Cancer Research Foundation
Beverly Hills, California, United States
Karen L. Reckamp
Recruiting
Kaiser Permanente Dublin
Dublin, California, United States
Jennifer M. Suga
Recruiting
Kaiser Permanente-Fremont
Fremont, California, United States
Jennifer M. Suga
Recruiting
Kaiser Permanente Fresno Orchard Plaza
Fresno, California, United States
Jennifer M. Suga
Recruiting
Uc San Diego Moores Cancer Center
La Jolla, California, United States
Amanda L. Herrmann
Recruiting
Veterans Affairs Loma Linda Healthcare System
Loma Linda, California, United States
Zarah Dulce F. Lucas
Recruiting
Cedars-Sinai Medical Center
Los Angeles, California, United States
Karen L. Reckamp
Recruiting
Kaiser Permanente- Modesto Mob Ii
Modesto, California, United States
Jennifer M. Suga
Recruiting
Kaiser Permanente-Oakland
Oakland, California, United States
Jennifer M. Suga
Recruiting
Kaiser Permanente-Roseville
Roseville, California, United States
Jennifer M. Suga
Recruiting
Kaiser Permanente Downtown Commons
Sacramento, California, United States
Jennifer M. Suga
Recruiting
Kaiser Permanente-South Sacramento
Sacramento, California, United States
Jennifer M. Suga
Recruiting
University of California Davis Comprehensive Cancer Center
Sacramento, California, United States
Surbhi Singhal
Recruiting
Kaiser Permanente-San Francisco
San Francisco, California, United States
Jennifer M. Suga
Recruiting
Kaiser Permanente-Santa Teresa-San Jose
San Jose, California, United States
Jennifer M. Suga
Recruiting
Kaiser Permanente San Leandro
San Leandro, California, United States
Jennifer M. Suga
Recruiting
Kaiser San Rafael-Gallinas
San Rafael, California, United States
Jennifer M. Suga
Recruiting
Kaiser Permanente Medical Center - Santa Clara
Santa Clara, California, United States
Jennifer M. Suga
Recruiting
Kaiser Permanente-Santa Rosa
Santa Rosa, California, United States
Jennifer M. Suga
Recruiting
Kaiser Permanente-South San Francisco
South San Francisco, California, United States
Jennifer M. Suga
Recruiting
Torrance Memorial Physician Network - Cancer Care
Torrance, California, United States
Karen L. Reckamp
Recruiting
Kaiser Permanente-Vallejo
Vallejo, California, United States
Jennifer M. Suga
Recruiting
Kaiser Permanente-Walnut Creek
Walnut Creek, California, United States
Jennifer M. Suga
Recruiting
Kaiser Permanente-Franklin
Denver, Colorado, United States
Matthew J. Eadens
Recruiting
Saint Mary'S Hospital and Regional Medical Center
Grand Junction, Colorado, United States
Patrick W. Cobb
Recruiting
Kaiser Permanente-Rock Creek
Lafayette, Colorado, United States
Matthew J. Eadens
Recruiting
Hartford Healthcare - Avon
Avon, Connecticut, United States
Krishna S. Gunturu
Recruiting
Hartford Hospital
Hartford, Connecticut, United States
Krishna S. Gunturu
Recruiting
Hartford Healthcare - Manchester
Manchester, Connecticut, United States
Krishna S. Gunturu
Recruiting
Midstate Medical Center
Meriden, Connecticut, United States
Krishna S. Gunturu
Recruiting
the Hospital of Central Connecticut
New Britain, Connecticut, United States
Krishna S. Gunturu
Recruiting
Beebe South Coastal Health Campus
Millville, Delaware, United States
Gregory A. Masters
Recruiting
Helen F Graham Cancer Center
Newark, Delaware, United States
Gregory A. Masters
Recruiting
Medical Oncology Hematology Consultants Pa
Newark, Delaware, United States
Gregory A. Masters
Recruiting
Beebe Health Campus
Rehoboth Beach, Delaware, United States
Gregory A. Masters
Recruiting
Morton Plant Hospital
Clearwater, Florida, United States
Ahmad Shaker
Recruiting
Miami Cancer Institute
Miami, Florida, United States
Bruna Pellini Ferreira
Recruiting
South Florida Baptist Hospital
Plant City, Florida, United States
Ahmad Shaker
Recruiting
Saint Anthony'S Hospital Cancer Care Center
St. Petersburg, Florida, United States
Ahmad Shaker
Recruiting

238 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Durvalumab

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 1 Apr 2025
Primary completion: 15 Jul 2039
Completion: 15 Jul 2039
Last update posted: 21 Aug 2026
Registered enrollment: 306
Registry id: NCT06498635

Cross-registrations

Other registry (CTRP (Clinical Trial Reporting ProgramNCI-2024-05588

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.