A Study of Neladalkib (NVL-655) in Patients With Advanced NSCLC and Other Solid Tumors Harboring ALK Rearrangement or Activating ALK Mutation (ALKOVE-1)
Summary
The lay summary the sponsor registered on ClinicalTrials.gov.
Investigators
The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.
- Viola Zhu, MD, PHD
Nuvalent Inc.
Study Director
A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.
Sites
74 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.
- Royal North Shore Hospital
Sydney, New South Wales, Australia
Malinda Itchins, MBBS PhDRecruiting - Princess Alexandra Hospital
Woolloongabba, Queensland, Australia
Kenneth O'Byrne, MDRecruiting - Peter Maccallum Cancer Centre
Melbourne, Victoria, Australia
Benjamin Solomon, MD, PhDRecruiting
- Universitair Ziekenhuis Antwerpen (uza)
Antwerp, Belgium
Reinier Wener, MDRecruiting - Universitaire Ziekenhuizen Leuven Campus Gastthuisberg
Leuven, Belgium
Christophe Dooms, MDRecruiting
- Cross Cancer Institute
Edmonton, Alberta, Canada
Quincy Siu Chung Chu, MDRecruiting - Bc Cancer Center
Vancouver, British Columbia, Canada
Barbara Melosky, MDRecruiting - the Ottawa Hospital Cancer Center
Ottawa, Ontario, Canada
Garth Nicholas, MDRecruiting - Princess Margaret Cancer Centre
Toronto, Ontario, Canada
Geoffrey Liu, M.D.Recruiting
- Centre Leon Berard
Lyon, France
Aurelie Swalduz, MDRecruiting - Chu de Nantes
Nantes, France
Elvire Pons-Tostivint, MD, PhDRecruiting - Institut Claudius Regaud
Toulouse, France
Julien Mazieres, MD, PhDRecruiting - Institute Gustave Roussy
Villejuif, France
Benjamin Besse, MD, PhDRecruiting
- Universitatsklinikum Koln - University Hospital Cologne
Cologne, Germany
Dr med Sebastian MichelsRecruiting - Universitätsklinikum Frankfurt
Frankfurt, Germany
Martin Sebastian, MDRecruiting - Lungenclinic Grosshansdorf Gmbh
Großhansdorf, Germany
Prof Dr Martin ReckRecruiting - Universkitatsklinikum Heidelberg - University Hospital Heidelberg
Heidelberg, Germany
Prof Dr med Petros ChristopoulosRecruiting
- Azienda Ospedaliera Universitaria Ospedali Riuniti Umberto
Ancona, Italy
Rossana Berardi, MDRecruiting - Irccs Istituto Tumori "g. Paolo Ii"
Bari, Italy
Domenico Galetta, MDRecruiting - Fondazione Irccs Istituto Nazionale Dei Tumori
Milan, Italy
Sara Cresta, MDRecruiting - Instituto Europeo Di Oncologia
Milan, Italy
Gianluca Spitaleri, MDRecruiting - Instituto Oncologico Veneto
Padova, Italy
Giulia Pasello, MDRecruiting - Ospedale Santa Maria Delle Croci
Ravenna, Italy
Chiara Bennati, MDRecruiting - Regina Elena Institute for Cancer Research
Rome, Italy
Lorenza Landi, MDRecruiting
- Kanagawa Cancer Center
Kanagawa, Japan
Tetsuro Kondo, MDRecruiting - Okayama University Hospital
Okayama, Japan
Kiichiro Ninomiya, MDRecruiting - Kindai University Hospital
Osaka, Japan
Junko Tanizaki, MDRecruiting - Shizuoka Cancer Center
Shizuoka, Japan
Ryo Ko, MD PhDRecruiting - Cancer Institute Hospital of Jfcr
Tokyo, Japan
Ryo Ariyasu, MDRecruiting - National Cancer Center Hospital
Tokyo, Japan
Tatsuya Yoshida, MDRecruiting - Wakayama Medical University Hospital
Wakayama, Japan
Hiroaki Akamatsu, MD, PhDRecruiting
- the Netherlands Cancer Institute
Amsterdam, Netherlands
Adrianus Joop de Langen, MDRecruiting - University Medical Center Groningen (umcg)
Groningen, Netherlands
AJ Van Der Wekken, MDRecruiting
- National Cancer Centre Singapore
Singapore, Singapore, Singapore
Aaron Tan, MDRecruiting - National University Hospital
Singapore, Singapore, Singapore
Ross Soo, MDRecruiting
- National Cancer Center
Goyang-si, Gyeonggi-do, South Korea
Ji-Youn Han, MDRecruiting - Samsung Medical Center
Seoul, South Korea
Myung-Ju Ahn, MDRecruiting - Seoul National University Hospital
Seoul, South Korea
Dong-wan Kim, MDRecruiting - Severance Hospital Yonsei University Health System
Seoul, South Korea
Byoung Chul Cho, MDRecruiting
- Complejo Hospitalario Universitario de A Coruna
A Coruña, Spain
Maria Campelo, MDRecruiting
Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.
Drugs studied
The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.
Registration & key dates
Registry attributes as recorded on the ClinicalTrials.gov study record.
- Start
- 9 Jun 2022
- Primary completion
- 31 Dec 2027
- Completion
- 31 Jan 2028
- Last update posted
- 27 May 2026
- Registered enrollment
- 840
- Registry id
- NCT05384626
Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.