Clinical trialNCT07143487RecruitingInterventional

Family Communications After Genetic Testing

SponsorAlliance for Clinical Trials in OncologyEnrollment4,186Colon AdenocarcinomaColorectal AdenocarcinomaRectal AdenocarcinomaStage I Colon Cancer AJCC v8Stage I Colorectal Cancer AJCC v8Stage I Rectal Cancer AJCC v8+9 more conditions

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This clinical trial compares patient (proband)-mediated communication to provider-mediated communication for improving genetic testing in first-degree relatives of patients with newly diagnosed colorectal cancer. It is estimated that 30% of cases of colorectal cancer have a genetic basis and about 15% of these patients have a disease-causing (pathogenic) inherited (germline) variant in a cancer susceptibility gene. Most individuals carrying a pathogenic germline variant are unaware of their cancer risk and may not meet guidelines for genetic testing. Identifying pathogenic germline variants or hereditary cancer syndromes in cancer patients has important implications for their at-risk relatives who may not know that they are at high risk for cancer. The burden of communicating this risk to first-degree relatives often falls on the patients, who may lack sufficient knowledge to correctly share and explain their genetic test results. Receiving provider-mediated communication of genetic testing results may be more effective at communicating genetic risk to first-degree relatives than the usual practice of proband-mediated communication.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Frank A Sinicrope
Alliance for Clinical Trials in Oncology
Study Chair
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

299 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Puerto Rico

Cancer Center-Metro Medical Center Bayamon
Bayamón, Puerto Rico
Luis J. Santos Reyes
Recruiting
Puerto Rico Hematology Oncology Group
Bayamón, Puerto Rico
Luis J. Santos Reyes
Recruiting
Doctors Cancer Center
Manati, Puerto Rico
Luis J. Santos Reyes
Recruiting
Centro Comprensivo de Cancer de Upr
San Juan, Puerto Rico
Luis J. Santos Reyes
Recruiting
Proncology
San Juan, Puerto Rico
Luis J. Santos Reyes
Recruiting
San Juan City Hospital
San Juan, Puerto Rico
Luis J. Santos Reyes
Recruiting
San Juan Community Oncology Group
San Juan, Puerto Rico
Luis J. Santos Reyes
Recruiting

United States

Alaska Breast Care and Surgery Llc
Anchorage, Alaska, United States
Alison K. Conlin
Recruiting
Alaska Oncology and Hematology Llc
Anchorage, Alaska, United States
Alison K. Conlin
Recruiting
Alaska Women'S Cancer Care
Anchorage, Alaska, United States
Alison K. Conlin
Recruiting
Anchorage Associates in Radiation Medicine
Anchorage, Alaska, United States
Alison K. Conlin
Recruiting
Katmai Oncology Group
Anchorage, Alaska, United States
Alison K. Conlin
Recruiting
Providence Alaska Medical Center
Anchorage, Alaska, United States
Alison K. Conlin
Recruiting
Fairbanks Memorial Hospital
Fairbanks, Alaska, United States
John M. Schallenkamp
Recruiting
Cancer Center at Saint Joseph'S
Phoenix, Arizona, United States
Shahzad Siddique
Recruiting
Mercy Hospital Fort Smith
Fort Smith, Arkansas, United States
Jay W. Carlson
Recruiting
Carti Cancer Center
Little Rock, Arkansas, United States
Jay W. Carlson
Recruiting
Mission Hope Medical Oncology - Arroyo Grande
Arroyo Grande, California, United States
Shahzad Siddique
Recruiting
Providence Saint Joseph Medical Center/disney Family Cancer Center
Burbank, California, United States
Alison K. Conlin
Recruiting
Mercy Cancer Center - Carmichael
Carmichael, California, United States
Shahzad Siddique
Recruiting
Mercy San Juan Medical Center
Carmichael, California, United States
Shahzad Siddique
Recruiting
Mercy Cancer Center - Elk Grove
Elk Grove, California, United States
Shahzad Siddique
Recruiting
Mercy Cancer Center
Merced, California, United States
Shahzad Siddique
Recruiting
Providence Queen of the Valley
Napa, California, United States
Alison K. Conlin
Recruiting
Mercy Cancer Center - Rocklin
Rocklin, California, United States
Shahzad Siddique
Recruiting
Mercy Cancer Center - Sacramento
Sacramento, California, United States
Shahzad Siddique
Recruiting
Pacific Central Coast Health Center-San Luis Obispo
San Luis Obispo, California, United States
Shahzad Siddique
Recruiting
Mission Hope Medical Oncology - Santa Maria
Santa Maria, California, United States
Shahzad Siddique
Recruiting
Providence Medical Foundation - Santa Rosa
Santa Rosa, California, United States
Alison K. Conlin
Recruiting
Providence Santa Rosa Memorial Hospital
Santa Rosa, California, United States
Alison K. Conlin
Recruiting
Saint Helena Hospital
St. Helena, California, United States
Ethan D. Schram
Recruiting
Saint Joseph'S Medical Center
Stockton, California, United States
Shahzad Siddique
Recruiting
Woodland Memorial Hospital
Woodland, California, United States
Shahzad Siddique
Recruiting
Penrose-Saint Francis Healthcare
Colorado Springs, Colorado, United States
Shahzad Siddique
Recruiting
Rocky Mountain Cancer Centers-Penrose
Colorado Springs, Colorado, United States
Shahzad Siddique
Recruiting
Saint Francis Cancer Center
Colorado Springs, Colorado, United States
Shahzad Siddique
Recruiting
Commonspirit Cancer Center Mercy
Durango, Colorado, United States
Shahzad Siddique
Recruiting
Mercy Medical Center
Durango, Colorado, United States
Shahzad Siddique
Recruiting
Commonspirit Saint Anthony Hospital Cancer Center
Lakewood, Colorado, United States
Shahzad Siddique
Recruiting
Longmont United Hospital
Longmont, Colorado, United States
Shahzad Siddique
Recruiting

259 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study. It may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 6 Apr 2026
Primary completion: 5 Nov 2029
Completion: 5 Nov 2032
Last update posted: 5 Aug 2026
Registered enrollment: 4,186
Registry id: NCT07143487

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.