Clinical trialNCT07353931RecruitingPhase 3Interventional

Efficacy and Safety of Eloralintide (LY3841136) in Participants With Osteoarthritis Knee Pain and Obesity or Overweight

SponsorEli Lilly and CompanyEnrollment900OsteoarthritisOverweight or Obesity

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The YDAN master protocol will support two independent studies, J3R-MC-YOA1 and J3R-MC-YOA2. Each study will investigate how well and safely Eloralintide (LY3841136) works in adults with obesity or overweight who have osteoarthritis (OA) of the knee with pain. Participation in the study will last about 75 weeks, including screening.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 8 AM - 8 PM Eastern time (UTC/GMT - 5 hours, EST)
Eli Lilly and Company
Study Director
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

152 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Argentina

Cardiamet Investigaciones Médicas
Buenos Aires, Argentina
Virginia Durigan
Not, yet, recruiting
Centro Médico Arsema
Buenos Aires, Argentina
Federico Ariel
Not, yet, recruiting
Centro Privado de Medicina Familiar / Mindout Research
Buenos Aires, Argentina
Leonardo Naftal
Not, yet, recruiting
Organizacion Medica de Investigacion
Buenos Aires, Argentina
Patricio Tate
Not, yet, recruiting
Stat Research S.A.
Buenos Aires, Argentina
ALEJANDRO ARROYO
Not, yet, recruiting
Centro de Investigaciones Clínicas Baigorria
Granadero Baigorria, Argentina
Juan Escalante
Not, yet, recruiting
Ineco Neurociencias Oroño
Rosario, Argentina
Florencia Garavelli
Not, yet, recruiting
Instituto Especialidades de la Salud Rosario
Rosario, Argentina
Julieta Gentiletti
Not, yet, recruiting
Centro de Investigaciones Médicas Tucuman
SAN M. de Tucuman, Argentina
Walter Spindler
Not, yet, recruiting
Medicina Reumatológica
San Fernando, Argentina
Maria Cusa
Not, yet, recruiting
Instituto de Alta Complejidad San Isidro
San Isidro, Argentina
Maria Lazaro
Not, yet, recruiting
Centro Polivalente de Asistencia E Investigacion Clinica - Cer San Juan
San Juan, Argentina
Rodolfo Pardo Hidalgo
Not, yet, recruiting
Centro de Investigaciones Reumatológicas
San Miguel de Tucumán, Argentina
Luciana Gonzalez Lucero
Not, yet, recruiting
Go Centro Medico San Nicolás
San Nicolás, Argentina
Paulina Lanchiotti
Not, yet, recruiting

Belgium

Antwerp University Hospital
Edegem, Belgium
eveline dirinck
Not, yet, recruiting
Reuma Clinic, Locatie Jaarbeurslaan
Genk, Belgium
Johan Vanhoof
Recruiting
Uz Gent
Ghent, Belgium
Ruth Wittoek
Recruiting
Kormont
Kluisbergen, Belgium
Klaas Vercruysse
Recruiting
Uz Leuven
Leuven, Belgium
Kurt de Vlam
Recruiting
Meclinas
Mechelen, Belgium
Julie Casaer
Recruiting
Zna Jan Palfijn
Merksem, Belgium
Alla Ishchenko
Not, yet, recruiting
Medisch Centrum Latem (hip Clinic) - Algemeen Ziekenhuis Maria Middelares Location
Sint-Martens-Latem, Belgium
Pieter Vansintjan
Not, yet, recruiting

Brazil

Centro de Pesquisa Sao Lucas
Campinas, Brazil
Suspended
Ibpclin - Instituto Brasil de Pesquisa Clínica
Rio de Janeiro, Brazil
Suspended
Cepic - Centro Paulista de Investigação Clínica
São Paulo, Brazil
Suspended
Cphosp Medicina, Ensino E Pesquisa (cpquali)
São Paulo, Brazil
Suspended
Hospital Das Clinicas Fmusp
São Paulo, Brazil
Suspended
Integra - Pesquisa Clínica E Infusões
São Paulo, Brazil
Suspended

Canada

Apex Trials
Guelph, Canada
Ken Woo
Recruiting
Diex Recherche Inc. Division Quebec
Québec, Canada
Caroline Rheaume
Recruiting
G.R.M.O. (groupe de Recherche En Maladies Osseuses) Inc.
Québec, Canada
Louis Bessette
Not, yet, recruiting
Stouffville Medical Research Institute Inc.
Stouffville, Canada
Nima Mirtorabi
Recruiting
Dr. Anil K. Gupta Medicine Professional Corporation
Toronto, Canada
Anil Gupta
Recruiting
Maple Leaf Research
Toronto, Canada
Mona Loutfy
Recruiting
Diex Recherche Inc. Division Victoriaville
Victoriaville, Canada
Eve Betit
Recruiting

China

Beijing Ji Shui Tan Hospital
Beijing, China
Xiaoli Deng
Not, yet, recruiting
the First Afflilated Hospital of Bengbu Medical College
Bengbu, China
Xiaoyun Fan
Recruiting
Jilin Province People'S Hospital
Changchun, China
Guoping Jiang
Recruiting
the Second Hospital of Jilin University
Changchun, China
Hanqing Cai
Not, yet, recruiting
Xiangya Hospital Central South University
Changsha, China
Wenfeng Xiao
Recruiting

112 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

EloralintidePlacebo

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 9 Feb 2026
Primary completion: 31 Mar 2028
Completion: 31 May 2028
Last update posted: 21 Aug 2026
Registered enrollment: 900
Registry id: NCT07353931

Cross-registrations

EU-CTR / CTIS (EudraCT)2025-523768-19-00

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.