Clinical trialNCT07589608RecruitingPhase 2Interventional

A Study to Investigate Weight Management With Macupatide and Eloralintide, Alone or in Combination, in Adult Participants With Obesity or Overweight

SponsorEli Lilly and CompanyEnrollment400ObesityOverweight

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The main purpose of this study, performed under the master protocol W8M-MC-CWMM (NCT06143956), is to examine the body weight-lowering efficacy and safety of macupatide plus eloralintide compared with placebo in participants with obesity or overweight and without type 2 diabetes. Participation will last about 64 weeks.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 8 AM - 8 PM Eastern time (UTC/GMT - 5 hours, EST)
Eli Lilly and Company
Study Director
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

40 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

the Institute for Liver Health Ii Dba Arizona Clinical Trials - Mesa
Chandler, Arizona, United States
Yessica Sachdeva
Recruiting
Headlands Research - Scottsdale
Scottsdale, Arizona, United States
Benjamin Clark
Recruiting
the Institute for Liver Health Ii Dba Arizona Liver Health-Tucson
Tucson, Arizona, United States
Anita Kohli
Recruiting
Norcal Medical Research, Inc
Greenbrae, California, United States
Linda Gaudiani
Recruiting
Velocity Clinical Research, Huntington Park
Huntington Park, California, United States
Stanley Hsia
Recruiting
Peninsula Research Associates
Rolling Hills Estates, California, United States
LeighAnn Schmidt
Recruiting
Diablo Clinical Research, Inc.
Walnut Creek, California, United States
Mark Christiansen
Recruiting
Stamford Therapeutics Consortium
Stamford, Connecticut, United States
David Radin
Recruiting
New Horizon Research Center
Miami, Florida, United States
Lazaro Nunez
Recruiting
Indago Research & Health Center, Inc
Miami Lakes, Florida, United States
Jose Cardona
Recruiting
Suncoast Clinical Research, Inc.
New Port Richey, Florida, United States
Cathy Barnes
Recruiting
Charter Research - Winter Park
Orlando, Florida, United States
Edgardo Rivera-Rivera
Recruiting
Charter Research - Lady Lake
The Villages, Florida, United States
Jeffrey Norton
Recruiting
Medical Research Partners
Ammon, Idaho, United States
Joseph Moore
Recruiting
Great Lakes Clinical Trials - Ravenswood
Chicago, Illinois, United States
Rupal Trivedi
Recruiting
Cotton O'Neil Diabetes & Endocrinology
Topeka, Kansas, United States
susan brian
Recruiting
Monroe Biomedical Research - Louisville
Louisville, Kentucky, United States
Harold Bays →
Recruiting
Knownwell
Needham, Massachusetts, United States
Angela Fitch
Recruiting
Lucida Clinical Trials
New Bedford, Massachusetts, United States
David Shih
Recruiting
Headlands Research - Detroit
Southfield, Michigan, United States
Christopher Romero
Recruiting
Arcturus Healthcare , Plc, Troy Internal Medicine Research Division
Troy, Michigan, United States
Neil Fraser
Recruiting
Studymetrix Research
City of Saint Peters, Missouri, United States
Timothy Smith
Recruiting
Clinvest Headlands Llc
Springfield, Missouri, United States
Christina Capps
Recruiting
Las Vegas Medical Research
Las Vegas, Nevada, United States
Cornell Calinescu
Recruiting
Dent Neurologic Institute
Amherst, New York, United States
Laszlo Mechtler
Recruiting
Rochester Clinical Research, Llc
Rochester, New York, United States
Patrick Connors
Recruiting
Medication Management
Greensboro, North Carolina, United States
James Franklin
Recruiting
Monroe Biomedical Research
Monroe, North Carolina, United States
Awawu Igbinadolor
Recruiting
Lucas Research, Inc
Morehead City, North Carolina, United States
Kathryn Lucas
Recruiting
Lucas Research, Inc.
New Bern, North Carolina, United States
Joseph Maides
Recruiting
Cti Clinical Research Center
Cincinnati, Ohio, United States
James Maynard
Recruiting
Tribe Clinical Research, Llc
Greenville, South Carolina, United States
Ronald Mayfield
Recruiting
Quality Medical Research
Nashville, Tennessee, United States
Saras Sharma
Recruiting
Ima Clinical Research Austin
Austin, Texas, United States
Nomita Kim
Recruiting
Futuresearch Trials of Dallas
Dallas, Texas, United States
Michael Downing
Recruiting
Planit Research, Pllc
Houston, Texas, United States
Amer Al-Karadsheh
Recruiting
Endeavor Clinical Trials
San Antonio, Texas, United States
Nitendra Agarwal
Recruiting
Texas Valley Clinical Research
Weslaco, Texas, United States
Eduardo Luna
Recruiting
Sovah Clinical Research-River District
Danville, Virginia, United States
Stephan Jannach
Recruiting
Central Washington Health Services Association D/b/a Confluence Health
Wenatchee, Washington, United States
Kathryn Eren
Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

EloralintideMacupatidePlacebo

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 15 May 2026
Primary completion: 30 Sept 2027
Completion: 29 Feb 2028
Last update posted: 6 Aug 2026
Registered enrollment: 400
Registry id: NCT07589608

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.