Clinical trialNCT00720083TerminatedPhase 2Interventional

Chemotherapy and Radiation Therapy (RT) With or Without Vandetanib in Treating Patients With High-Risk Stage III or Stage IV Head and Neck Cancer

SponsorRadiation Therapy Oncology GroupEnrollment34Head and Neck Cancer

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

RATIONALE: Drugs used in chemotherapy, such as cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Radiation therapy uses high-energy x-rays to kill tumor cells. Vandetanib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. It is not yet known whether giving chemotherapy together with radiation therapy is more effective with or without vandetanib in treating patients with head and neck cancer. PURPOSE: This randomized phase II trial is studying giving chemotherapy together with radiation therapy to see how well it works compared with giving chemotherapy and radiation therapy together with vandetanib in treating patients with high-risk stage III or stage IV head and neck cancer.

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Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

David Raben, MD
University of Colorado, Denver
Principal Investigator
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John A. Ridge, MD, PhD
Fox Chase Cancer Center
Study Chair
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Stuart J. Wong, MD
Medical College of Wisconsin
Study Chair
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A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

63 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Mayo Clinic Scottsdale
Scottsdale, Arizona, United States
City of Hope Comprehensive Cancer Center
Duarte, California, United States
Rebecca and John Moores Ucsd Cancer Center
La Jolla, California, United States
Usc/norris Comprehensive Cancer Center and Hospital
Los Angeles, California, United States
Radiological Associates of Sacramento Medical Group, Incorporated
Sacramento, California, United States
Ccop - Christiana Care Health Services
Newark, Delaware, United States
Mayo Clinic - Jacksonville
Jacksonville, Florida, United States
Winship Cancer Institute of Emory University
Altanta, Georgia, United States
Ingalls Cancer Care Center at Ingalls Memorial Hospital
Harvey, Illinois, United States
Cancer Institute at St. John'S Hospital
Springfield, Illinois, United States
Saint John'S Cancer Center at Saint John'S Medical Center
Anderson, Indiana, United States
Methodist Cancer Center at Methodist Hospital
Indianapolis, Indiana, United States
Kansas Masonic Cancer Research Institute at the University of Kansas Medical Center
Kansas City, Kansas, United States
James Graham Brown Cancer Center at University of Louisville
Louisville, Kentucky, United States
Charach Cancer Center at Huron Valley - Sinai Hospital
Commerce, Michigan, United States
Barbara Ann Karmanos Cancer Institute
Detroit, Michigan, United States
Josephine Ford Cancer Center at Henry Ford Hospital
Detroit, Michigan, United States
Mayo Clinic Cancer Center
Rochester, Minnesota, United States
Regional Cancer Center at Singing River Hospital
Pascagoula, Mississippi, United States
Ccop - Kansas City
Kansas City, Missouri, United States
Truman Medical Center - Hospital Hill
Kansas City, Missouri, United States
David C. Pratt Cancer Center at St. John'S Mercy
St Louis, Missouri, United States
Saint Elizabeth Cancer Institute at Saint Elizabeth Regional Medical Center
Lincoln, Nebraska, United States
Renown Institute for Cancer at Renown Regional Medical Center
Reno, Nevada, United States
Memorial Sloan-Kettering Cancer Center - Basking Ridge
Basking Ridge, New Jersey, United States
Radiation Oncology Associates, Pa
Albuquerque, New Mexico, United States
University of New Mexico Cancer Center
Albuquerque, New Mexico, United States
Roswell Park Cancer Institute
Buffalo, New York, United States
Memorial Sloan-Kettering Cancer Center
Commack, New York, United States
Highland Hospital of Rochester
Rochester, New York, United States
James P. Wilmot Cancer Center at University of Rochester Medical Center
Rochester, New York, United States
Memorial Sloan-Kettering Cancer Center - Rockville Centre
Rockville Centre, New York, United States
Memorial Sloan-Kettering Cancer Center at Phelps Memorial Hospital Center
Sleepy Hollow, New York, United States
Leo W. Jenkins Cancer Center at Ecu Medical School
Greenville, North Carolina, United States
Summa Center for Cancer Care at Akron City Hospital
Akron, Ohio, United States
Barberton Citizens Hospital
Barberton, Ohio, United States
Case Comprehensive Cancer Center
Cleveland, Ohio, United States
Cleveland Clinic Taussig Cancer Center
Cleveland, Ohio, United States
Lake/university Ireland Cancer Center
Mentor, Ohio, United States
North Coast Cancer Care, Incorporated
Sandusky, Ohio, United States

23 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Cisplatin →Vandetanib →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 30 Nov 2008
Primary completion: 31 Aug 2011
Completion: 31 Aug 2011
Last update posted: 17 Nov 2015
Registered enrollment: 34
Registry id: NCT00720083

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.