Clinical trialNCT02523014RecruitingPhase 2Interventional

Vismodegib, FAK Inhibitor GSK2256098, Capivasertib, and Abemaciclib in Treating Patients With Progressive Meningiomas

SponsorAlliance for Clinical Trials in OncologyEnrollment124Intracranial MeningiomaNF2 Gene MutationRecurrent Meningioma

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This phase II trial studies how well vismodegib, focal adhesion kinase (FAK) inhibitor GSK2256098, and capivasertib work in treating patients with meningioma that is growing, spreading, or getting worse (progressive). Vismodegib, FAK inhibitor GSK2256098, capivasertib, and abemaciclib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Priscilla Brastianos, MD
Massachusetts General Hospital
Study Chair
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

783 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

University of Alabama at Birmingham Cancer Center
Birmingham, Alabama, United States
Active, not recruiting
Alaska Breast Care and Surgery Llc
Anchorage, Alaska, United States
Alison K. Conlin
Recruiting
Alaska Oncology and Hematology Llc
Anchorage, Alaska, United States
Alison K. Conlin
Recruiting
Alaska Women'S Cancer Care
Anchorage, Alaska, United States
Alison K. Conlin
Recruiting
Anchorage Associates in Radiation Medicine
Anchorage, Alaska, United States
Alison K. Conlin
Recruiting
Anchorage Oncology Centre
Anchorage, Alaska, United States
Suspended
Anchorage Radiation Therapy Center
Anchorage, Alaska, United States
Suspended
Katmai Oncology Group
Anchorage, Alaska, United States
Alison K. Conlin
Recruiting
Providence Alaska Medical Center
Anchorage, Alaska, United States
Alison K. Conlin
Recruiting
Fairbanks Memorial Hospital
Fairbanks, Alaska, United States
John M. Schallenkamp
Recruiting
Kingman Regional Medical Center
Kingman, Arizona, United States
John A. Ellerton
Recruiting
Cancer Center at Saint Joseph'S
Phoenix, Arizona, United States
Shahzad Siddique
Recruiting
Saint Joseph'S Hospital and Medical Center
Phoenix, Arizona, United States
Suspended
Arizona Oncology Services Foundation
Scottsdale, Arizona, United States
Suspended
Mayo Clinic in Arizona
Scottsdale, Arizona, United States
Withdrawn
Mercy Hospital Fort Smith
Fort Smith, Arkansas, United States
Jay W. Carlson
Recruiting
Chi Saint Vincent Cancer Center Hot Springs
Hot Springs, Arkansas, United States
Suspended
Carti Cancer Center
Little Rock, Arkansas, United States
Jay W. Carlson
Recruiting
Kaiser Permanente-Deer Valley Medical Center
Antioch, California, United States
Active, not recruiting
Mission Hope Medical Oncology - Arroyo Grande
Arroyo Grande, California, United States
Shahzad Siddique
Recruiting
Pcr Oncology
Arroyo Grande, California, United States
John A. Ellerton
Recruiting
Sutter Auburn Faith Hospital
Auburn, California, United States
Active, not recruiting
Sutter Cancer Centers Radiation Oncology Services-Auburn
Auburn, California, United States
Active, not recruiting
Alta Bates Summit Medical Center-Herrick Campus
Berkeley, California, United States
Active, not recruiting
Providence Saint Joseph Medical Center/disney Family Cancer Center
Burbank, California, United States
Alison K. Conlin
Recruiting
Mills-Peninsula Medical Center
Burlingame, California, United States
Active, not recruiting
Sutter Cancer Centers Radiation Oncology Services-Cameron Park
Cameron Park, California, United States
Active, not recruiting
Mercy Cancer Center - Carmichael
Carmichael, California, United States
Shahzad Siddique
Recruiting
Mercy San Juan Medical Center
Carmichael, California, United States
Shahzad Siddique
Recruiting
Eden Hospital Medical Center
Castro Valley, California, United States
Active, not recruiting
Sutter Davis Hospital
Davis, California, United States
Active, not recruiting
Mercy Cancer Center - Elk Grove
Elk Grove, California, United States
Shahzad Siddique
Recruiting
Kaiser Permanente-Fremont
Fremont, California, United States
Active, not recruiting
Palo Alto Medical Foundation-Fremont
Fremont, California, United States
Active, not recruiting
Kaiser Permanente-Fresno
Fresno, California, United States
Active, not recruiting
Uc San Diego Moores Cancer Center
La Jolla, California, United States
David E. Piccioni
Recruiting
Cedars-Sinai Medical Center
Los Angeles, California, United States
Jeremy D. Rudnick
Recruiting
Kaiser Permanente Los Angeles Medical Center
Los Angeles, California, United States
Richard M. Green
Recruiting
Los Angeles General Medical Center
Los Angeles, California, United States
Active, not recruiting
Usc / Norris Comprehensive Cancer Center
Los Angeles, California, United States
Active, not recruiting

743 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Abemaciclib →Capivasertib →FAK Inhibitor GSK2256098Vismodegib →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 28 Sept 2015
Primary completion: 1 Jan 2027
Completion: 31 Jan 2028
Last update posted: 5 Aug 2026
Registered enrollment: 124
Registry id: NCT02523014

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.