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Clinical trialNCT03583710RecruitingPhase 3Interventional

Mitotane With or Without Cisplatin and Etoposide After Surgery in Treating Patients With Stage I-III Adrenocortical Cancer With High Risk of Recurrence

SponsorM.D. Anderson Cancer CenterEnrollment240ENSAT Stage I Adrenal Cortex CarcinomaENSAT Stage II Adrenal Cortex CarcinomaENSAT Stage III Adrenal Cortex Carcinoma
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This phase III trial studies how well mitotane alone works compared to mitotane with cisplatin and etoposide when given after surgery in treating patients with adrenocortical cancer that has a high risk of coming back (recurrence). Cortisol can cause the growth of adrenocortical tumor cells. Antihormone therapy, such as mitotane, may lessen the amount of cortisol made by the body. Drugs used in chemotherapy, such as cisplatin and etoposide, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. It is not yet known whether mitotane alone or mitotane with cisplatin and etoposide after surgery works better in treating patients with adrenocortical carcinoma.
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

33 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

France
  • Chu Angers, Hôpital Larrey

    Angers, France

    Sandrine Laboureau, MD
    Recruiting
  • Institut de Cancérologie de L'Ouest (ico)

    Angers, France

    Active, not recruiting
  • Chu Besançon, Hôpital Jean Minjoz

    Besançon, France

    Emmanuel N'Guyen, MD
    Recruiting
  • Chu Brest, Hôpital la Cavale Blanche

    Brest, France

    Active, not recruiting
  • Centre Georges François Leclerc

    Dijon, France

    Sylvie Zanetta, MD
    Recruiting
  • Hcl Hôpital Louis Pradel

    Lyon, France

    Hélène Lasolle, MD
    Not, yet, recruiting
  • Lyon Hcl

    Lyon, France

    Hélène Lasolle, MD
    Recruiting
  • Marseille Hôpital Nord

    Marseille, France

    Marie-Eve Garcia, MD
    Recruiting
  • Marseille Hôpital de la Conception

    Marseille, France

    Pr Fréderic Castinetti, MD
    Recruiting
  • Chu Nantes, Hôpital René Et Guillaume laënnec

    Nantes, France

    Alexandre Lugat, MD
    Recruiting
  • Chu Nantes, Hôpital René Et Guillaume laënnec

    Nantes, France

    Active, not recruiting
  • Hôpital Cochin

    Paris, France

    Active, not recruiting
  • Hôpital Cochin

    Paris, France

    Rossella LIBÉ LIBÉ, MD
    Recruiting
  • Hôpital Cochin, Ap-Hp

    Paris, France

    Active, not recruiting
  • Hôpital Cochin, Ap-Hp

    Paris, France

    Rossella Libé, MD
    Recruiting
  • Chu Bordeaux - Hôpital Haut Lévèque

    Pessac, France

    Magalie Haissaguerre, MD
    Recruiting
  • Chu Poitiers

    Poitiers, France

    Aurélie Miot, MD
    Recruiting
  • Chu Reims

    Reims, France

    Bénédicte Decoudier, MD
    Recruiting
  • Hus, Hôpital Hautepierre

    Strasbourg, France

    Philippe Baltzinger, MD
    Not, yet, recruiting
  • Strasbourg Hus Hautepierre

    Strasbourg, France

    Active, not recruiting
  • Chu Toulouse, Hôpital Larrey

    Toulouse, France

    Delphine Vezzosi, MD
    Recruiting
  • Chu Toulouse, Hôpital Rangueil

    Toulouse, France

    Active, not recruiting
  • Gustave Roussy

    Villejuif, France

    Eric Baudin, MD
    Recruiting
Germany
  • Lmu Klinikum München

    Munich, Germany

    Nicole Reisch, MD
    Recruiting
  • Universitätsklinikum Würzburg

    Würzburg, Germany

    Martin Fassnacht, MD
    Recruiting
Poland
  • Maria Sklodowska-Curie National Research Institute of Oncology

    Gliwice, Poland

    Active, not recruiting
Sweden
  • Sahlgrenska University Hospital

    Gothenburg, Sweden

    Andreas Hallqvist
    Recruiting
  • Skånes Universitetssjukhus

    Lund, Sweden

    Carl Fredrik Warfvinge, MD
    Recruiting
  • Karolinska University Hospital

    Stockholm, Sweden

    David Goldstein
    Recruiting
  • Akademiska Sjukhuset

    Uppsala, Sweden

    Joakim Crona
    Recruiting
United States
  • University of Michigan Comprehensive Cancer Center

    Ann Arbor, Michigan, United States

    Francis P. Worden →
    Recruiting
  • Siteman Cancer Center at Washington University

    St Louis, Missouri, United States

    Active, not recruiting
  • M D Anderson Cancer Center

    Houston, Texas, United States

    Jeena Varghese
    Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Cisplatin →Etoposide →Mitotane →
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
20 Aug 2018
Primary completion
1 Jan 2029
Completion
1 Jan 2029
Last update posted
16 Jul 2026
Registered enrollment
240
Registry id
NCT03583710
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 30 Jul 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.