Clinical trialNCT06124157RecruitingPhase 2Interventional

A Study Testing the Combination of Dasatinib or Imatinib to Chemotherapy Treatment With Blinatumomab for Children, Adolescents, and Young Adults With Philadelphia Chromosome Positive (Ph+) or ABL-Class Philadelphia Chromosome-Like (Ph-Like) B-cell Acute Lymphoblastic Leukemia (B-ALL)

SponsorNational Cancer Institute (NCI)Enrollment222B Acute Lymphoblastic Leukemia

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This pilot trial assesses the effect of the combination of blinatumomab with dasatinib or imatinib and standard chemotherapy for treating patients with Philadelphia chromosome positive (Ph+) or ABL-class Philadelphia chromosome-like (Ph-like) B-Cell acute lymphoblastic leukemia (B-ALL). Blinatumomab is a bispecific antibody that binds to two different proteins-one on the surface of cancer cells and one on the surface of cells in the immune system. An antibody is a protein made by the immune system to help fight infections and other harmful processes/cells/molecules. Blinatumomab may bind to the cancer cell and a T cell (which plays a key role in the immune system's fighting response) at the same time. Blinatumomab may strengthen the immune system's ability to fight cancer cells by activating the body's own immune cells to destroy the tumor. Dasatinib and imatinib are in a class of medications called tyrosine kinase inhibitors. They work by blocking the action of an abnormal protein that signals cancer cells to multiply, which may help keep cancer cells from growing. Giving blinatumomab and dasatinib or imatinib in combination with standard chemotherapy may work better in treating patients with Ph+ or Ph-like ABL-class B-ALL than dasatinib or imatinib with chemotherapy.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Thai Hoa Tran
Children's Oncology Group
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

156 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Australia

John Hunter Children'S Hospital
Hunter Regional Mail Centre, New South Wales, Australia
Kristy McCarthy
Recruiting
Queensland Children'S Hospital
South Brisbane, Queensland, Australia
Suspended
Perth Children'S Hospital
Perth, Western Australia, Australia
Michelle Ng
Recruiting

Canada

Alberta Children'S Hospital
Calgary, Alberta, Canada
Victor A. Lewis
Recruiting
University of Alberta Hospital
Edmonton, Alberta, Canada
Sarah J. McKillop
Recruiting
British Columbia Children'S Hospital
Vancouver, British Columbia, Canada
Suspended
Cancercare Manitoba
Winnipeg, Manitoba, Canada
Stephanie M. Villeneuve
Recruiting
Iwk Health Centre
Halifax, Nova Scotia, Canada
Chelsea Ash
Recruiting
Mcmaster Children'S Hospital at Hamilton Health Sciences
Hamilton, Ontario, Canada
Uma H. Athale
Recruiting
Hospital for Sick Children
Toronto, Ontario, Canada
Sumit Gupta
Recruiting
Centre Hospitalier Universitaire Sainte-Justine
Montreal, Quebec, Canada
Monia Marzouki
Recruiting
the Montreal Children'S Hospital of the Muhc
Montreal, Quebec, Canada
Stephanie Mourad
Recruiting
Centre Hospitalier Universitaire de Sherbrooke-Fleurimont
Sherbrooke, Quebec, Canada
Josee Brossard
Recruiting
Chu de Quebec-Centre Hospitalier de L'Universite Laval (chul)
Québec, Canada
Bruno Michon
Recruiting

Puerto Rico

University Pediatric Hospital
San Juan, Puerto Rico
Maria E. Echevarria
Recruiting

United States

Children'S Hospital of Alabama
Birmingham, Alabama, United States
Matthew A. Kutny
Recruiting
Phoenix Childrens Hospital
Phoenix, Arizona, United States
Dana B. Salzberg
Recruiting
Banner University Medical Center - Tucson
Tucson, Arizona, United States
Monica M. Davini
Recruiting
Arkansas Children'S Hospital
Little Rock, Arkansas, United States
Michael W. Bishop
Recruiting
Kaiser Permanente Downey Medical Center
Downey, California, United States
Robert M. Cooper
Recruiting
Loma Linda University Medical Center
Loma Linda, California, United States
Albert Kheradpour
Recruiting
Miller Children'S and Women'S Hospital Long Beach
Long Beach, California, United States
Jacqueline N. Casillas
Recruiting
Children'S Hospital Los Angeles
Los Angeles, California, United States
Andrew Doan
Recruiting
Valley Children'S Hospital
Madera, California, United States
Ruetima Titapiwatanakun
Recruiting
Kaiser Permanente-Oakland
Oakland, California, United States
Aarati V. Rao
Recruiting
Ucsf Benioff Children'S Hospital Oakland
Oakland, California, United States
Karen R. Rabin
Recruiting
Children'S Hospital of Orange County
Orange, California, United States
Elyssa M. Rubin
Recruiting
Lucile Packard Children'S Hospital Stanford University
Palo Alto, California, United States
Jay Michael S. Balagtas
Recruiting
University of California Davis Comprehensive Cancer Center
Sacramento, California, United States
Marcio H. Malogolowkin
Recruiting
Rady Children'S Hospital - San Diego
San Diego, California, United States
William D. Roberts
Recruiting
Ucsf Medical Center-Mission Bay
San Francisco, California, United States
Karen R. Rabin
Recruiting
Children'S Hospital Colorado
Aurora, Colorado, United States
Kelly W. Maloney
Recruiting
Connecticut Children'S Medical Center
Hartford, Connecticut, United States
Michael S. Isakoff
Recruiting
Yale University
New Haven, Connecticut, United States
Farzana Pashankar
Recruiting
Alfred I Dupont Hospital for Children
Wilmington, Delaware, United States
Emi H. Caywood
Recruiting
Children'S National Medical Center
Washington D.C., District of Columbia, United States
Jeffrey S. Dome
Recruiting
Medstar Georgetown University Hospital
Washington D.C., District of Columbia, United States
Caileigh Pudela
Recruiting
Golisano Children'S Hospital of Southwest Florida
Fort Myers, Florida, United States
Emad K. Salman
Recruiting
Uf Health Cancer Institute - Gainesville
Gainesville, Florida, United States
Brian Stover
Recruiting
Memorial Regional Hospital/joe Dimaggio Children'S Hospital
Hollywood, Florida, United States
Iftikhar Hanif
Recruiting

116 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Blinatumomab →Calaspargase pegol →Cyclophosphamide →Cytarabine →Dasatinib →Daunorubicin →Doxorubicin →Imatinib →Leucovorin →Mercaptopurine →Methotrexate →Pegaspargase →Prednisolone →Prednisone →ThioguanineVincristine →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 30 May 2025
Primary completion: 1 Dec 2030
Completion: 1 Dec 2030
Last update posted: 5 Aug 2026
Registered enrollment: 222
Registry id: NCT06124157

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.