Clinical trialNCT06401330RecruitingPhase 3Interventional

A Study Using Risk Factors to Determine Treatment for Children With Favorable Histology Wilms Tumors (FHWT)

SponsorChildren's Oncology GroupEnrollment1,656Stage I Mixed Cell Type Kidney Wilms TumorStage II Mixed Cell Type Kidney Wilms TumorStage III Mixed Cell Type Kidney Wilms TumorStage IV Mixed Cell Type Kidney Wilms Tumor

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This phase III trial studies using risk factors in determining treatment for children with favorable tissue (histology) Wilms tumors (FHWT). Wilms Tumor is the most common type of kidney cancer in children, and FHWT is the most common subtype. Previous large clinical trials have established treatment plans that are likely to cure most children with FHWT, however some children still have their cancer come back (called relapse) and not all survive. Previous research has identified features of FHWT that are associated with higher or lower risks of relapse. The term "risk" refers to the chance of the cancer coming back after treatment. Using results of tumor histology tests, biology tests, and response to therapy may be able to improve treatment for children with FHWT.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Elizabeth A Mullen
Children's Oncology Group
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

159 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Australia

Queensland Children'S Hospital
South Brisbane, Queensland, Australia
Steven A. Foresto
Recruiting

Canada

Alberta Children'S Hospital
Calgary, Alberta, Canada
Victor A. Lewis
Recruiting
University of Alberta Hospital
Edmonton, Alberta, Canada
Sarah J. McKillop
Recruiting
Cancercare Manitoba
Winnipeg, Manitoba, Canada
Stephanie M. Villeneuve
Recruiting
Iwk Health Centre
Halifax, Nova Scotia, Canada
Craig Erker
Recruiting
Mcmaster Children'S Hospital at Hamilton Health Sciences
Hamilton, Ontario, Canada
Uma H. Athale
Recruiting
Children'S Hospital
London, Ontario, Canada
Shayna M. Zelcer
Recruiting
Children'S Hospital of Eastern Ontario
Ottawa, Ontario, Canada
Donna L. Johnston
Recruiting
Hospital for Sick Children
Toronto, Ontario, Canada
Avram E. Denburg
Recruiting
Centre Hospitalier Universitaire Sainte-Justine
Montreal, Quebec, Canada
Monia Marzouki
Recruiting
the Montreal Children'S Hospital of the Muhc
Montreal, Quebec, Canada
Stephanie Mourad
Recruiting
Centre Hospitalier Universitaire de Sherbrooke-Fleurimont
Sherbrooke, Quebec, Canada
Josee Brossard
Recruiting
Chu de Quebec-Centre Hospitalier de L'Universite Laval (chul)
Québec, Canada
Bruno Michon
Recruiting

United States

Children'S Hospital of Alabama
Birmingham, Alabama, United States
Jamie M. Aye
Recruiting
Usa Health Strada Patient Care Center
Mobile, Alabama, United States
Hamayun Imran
Recruiting
Providence Alaska Medical Center
Anchorage, Alaska, United States
Brenda J. Wittman
Recruiting
Banner Children'S at Desert
Mesa, Arizona, United States
Joseph C. Torkildson
Recruiting
Phoenix Childrens Hospital
Phoenix, Arizona, United States
Alok K. Kothari
Recruiting
Arkansas Children'S Hospital
Little Rock, Arkansas, United States
Michael W. Bishop
Recruiting
Kaiser Permanente Downey Medical Center
Downey, California, United States
Robert M. Cooper
Recruiting
Loma Linda University Medical Center
Loma Linda, California, United States
Albert Kheradpour
Recruiting
Miller Children'S and Women'S Hospital Long Beach
Long Beach, California, United States
Jacqueline N. Casillas
Recruiting
Cedars-Sinai Medical Center
Los Angeles, California, United States
Leo Mascarenhas
Recruiting
Valley Children'S Hospital
Madera, California, United States
Ruetima Titapiwatanakun
Recruiting
Kaiser Permanente-Oakland
Oakland, California, United States
Aarati V. Rao
Recruiting
Ucsf Benioff Children'S Hospital Oakland
Oakland, California, United States
Natalie L. Wu
Recruiting
Children'S Hospital of Orange County
Orange, California, United States
Elyssa M. Rubin
Recruiting
Lucile Packard Children'S Hospital Stanford University
Palo Alto, California, United States
Jay Michael S. Balagtas
Recruiting
University of California Davis Comprehensive Cancer Center
Sacramento, California, United States
Marcio H. Malogolowkin
Recruiting
Rady Children'S Hospital - San Diego
San Diego, California, United States
William D. Roberts
Recruiting
Ucsf Medical Center-Mission Bay
San Francisco, California, United States
Natalie L. Wu
Recruiting
Children'S Hospital Colorado
Aurora, Colorado, United States
Sandra Luna-Fineman
Recruiting
Rocky Mountain Hospital for Children-Presbyterian Saint Luke'S Medical Center
Denver, Colorado, United States
Florence Choo
Recruiting
Connecticut Children'S Medical Center
Hartford, Connecticut, United States
Michael S. Isakoff
Recruiting
Yale University
New Haven, Connecticut, United States
Farzana Pashankar
Recruiting
Alfred I Dupont Hospital for Children
Wilmington, Delaware, United States
Vibhuti Agarwal
Recruiting
Children'S National Medical Center
Washington D.C., District of Columbia, United States
Jeffrey S. Dome
Recruiting
Broward Health Medical Center
Fort Lauderdale, Florida, United States
Hector M. Rodriguez-Cortes
Recruiting
Golisano Children'S Hospital of Southwest Florida
Fort Myers, Florida, United States
Emad K. Salman
Recruiting
Uf Health Cancer Institute - Gainesville
Gainesville, Florida, United States
Brian Stover
Recruiting

119 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Carboplatin →Cyclophosphamide →DactinomycinDoxorubicin →Etoposide →Irinotecan →Vincristine →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 15 Apr 2025
Primary completion: 13 Feb 2031
Completion: 13 Feb 2031
Last update posted: 5 May 2026
Registered enrollment: 1,656
Registry id: NCT06401330

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.